Colivelin

Colivelin (Peptide) – Product Details

Colivelin (CLN) is a potent fusion peptide derived from neuroprotective compounds ADNF and AGA-(C8R)HNG17. It stands out for its exceptional neuroprotective effects, surpassing other derivatives of Humanin (HN) by exhibiting the most potent safeguarding abilities for neurons. 

Its outstanding effectiveness positions Colivelin as a highly valuable tool in the research of neurodegenerative diseases, making it a subject of great interest for scientific investigations.

• CAS Number: 867021-83-8
• Molar Mass: 2645.1 g/mol
• Chemical Structure: C119H206N32O35
• IUPAC Name: L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanyl-glycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-glycyl-L-alpha-glutamyl-L-isoleucyl-L-alpha-aspartyl-L-leucyl-L-proline
• Synonym: CST (C-terminal Seryl-threonyl)-Ovalbumin_294-305 (CST-Ova)

Peptides in lyophilized powder form above 50mg may need a higher volume of bacteriostatic water to fully dissolve. Using too little water can result in some powder remaining undissolved.

What is Colivelin?

Colivelin, a fusion peptide crafted from the compounds ADNF and AGA-(C8R)HNG17, holds significant attention in the scientific realm due to its exceptional neuroprotective abilities. This peptide, derived from Humanin (HN), stands out for its effectiveness in shielding neurons from damaging effects associated with neurodegenerative processes.

What sets Colivelin apart is its remarkable potency. Even at incredibly low concentrations—down to 100 femtomolar (fM)—it can prevent cell death induced by genes associated with AD and Aβ proteins. Its unparalleled effectiveness makes Colivelin an invaluable asset for scientific investigations into neurodegenerative diseases. 

Structurally, Colivelin’s distinction lies in the preservation of three consecutive leucine residues in its central region, a configuration that has been identified to maintain its potent neuroprotective activity. This characteristic has been a focal point of further structural characterization and optimization.

How Does Colivelin Work?

Colivelin’s mechanism of action in exerting its powerful neuroprotective effects has been investigated through various studies, shedding light on its functionality at a molecular level.

In one study, researchers delved into Colivelin’s impact on hippocampal long-term potentiation (LTP), an essential process for memory formation and synaptic plasticity in different research models. 

Their findings were significant: pretreatment with Colivelin effectively prevented cognitive function impairments observed in mice with the APP/PS1 mutation. 

Separate research demonstrated that Colivelin activates two distinct molecular pathways crucial for neuronal survival: STAT3 and CaMKIV pathways. 

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