GDF-8 (Peptide) – Product Details

GDF 8 is a potential negative regulator of skeletal muscle growth. This secreted protein in the transforming growth factor β family possibly binds activin type ii receptors and potentially inhibits skeletal muscle mass and growth. Studies show recombinant GDF 8 potentially limits muscle hypertrophy in mice models, rat models, pig models, and human participants.

Use GDF 8 to study myostatin inhibition, activate Smad signaling, regulate embryonic development, and control skeletal muscle atrophy. Its potential effects on muscle mass make it promising for testing therapies for muscular dystrophy, cardiac issues, and more.

Disclaimer: This product is for research use only, not for human consumption. Handle with caution, avoiding repeated freeze-thaw cycles to maintain active protein. Molecular weight approx. 25 kDa. Further clinical trials are needed to evaluate safety and efficacy in human test subjects.

• CAS Number: 901758-09-6
• Molar Mass: 42750g.mol-1
• Chemical Formula: C221H366N72O67S
• Synonyms: Myostatin, GDF-8, MSTN, Growth/differentiation factor 8, Growth and differentiation factor-associated serum protein-1 (GASP-1)

What is GDF-8?

 GDF 8, also known as myostatin, is a secreted growth differentiation factor protein that acts as a potential negative regulator of skeletal muscle growth and mass. It is possibly a potent negative regulator that binds to activin type ii receptors and inhibits muscle hypertrophy. 

Recombinant GDF 8 is the active protein form that may be added to human sample types, mouse sample types, rat sample types, or porcine sample types to study myostatin inhibition in research assay kits.

Functionally, when myostatin binds receptors, it may activate Smad signaling and may impact embryonic development, adult skeletal muscle, and cardiac muscle development. Its potential effects on limiting muscle mass make it an intriguing protein to research for conditions like muscular dystrophy and skeletal muscle atrophy. However, further clinical trials are needed before use in human test subjects.  

For now, GDF 8 remains a useful tool for researching muscle growth factors across cell and animal models. Using recombinant myostatin allows scientists to better understand its potential and limits for regulating proteins and muscle mass.

Potential Applications of GDF-8 Myostatin

GDF 8, also called myostatin, is a highly conserved, secreted protein that acts as a negative regulator of skeletal muscle growth. Expressing this transforming growth factor beta superfamily member specifically in muscle cells potentially offers a useful tool for studying myoblast proliferation and differentiation.

GDF 8’s role in ovarian reproduction and Folliculogenesis

GDF-8 (growth differentiation factor-8) is a protein that potentially controls ovarian function and fertility. GDF-8 has been shown in cell and animal studies to possibly influence hormone production, cell growth, and other ovarian processes. GDF-8 signaling potentially influences steroid hormones, gonadotropin (reproductive hormone) responsiveness, glucose metabolism, cell proliferation, and gene expression in ovarian cells. [R]

GDF-8 is abundant in the ovaries and blood serum of obese or polycystic ovary syndrome women test subjects. During controlled ovarian stimulation treatments for infertility, GDF-8 levels change dynamically. Furthermore, GDF-8 expression is possibly linked to ovarian response to stimulation and the success of in vitro fertilization procedures. [R]

GDF-8 signaling inhibition could be used to treat ovarian hyperstimulation syndrome and ovulation problems in polycystic ovary syndrome. [R]

Improve insulin sensitivity and glucose metabolism

GDF8  potentially appears to play an important role in weight loss in skeletal muscle. Levels of GDF-8 were found to possibly decrease in leg muscle biopsies after weight loss surgery (gastric bypass). Also, levels of GDF8 were higher in abdominal muscle samples from extremely obese women participants compared to lean women test subjects. [R]

Using a computer analysis program, researchers found that GDF8 interacts with other genes and proteins that are known to be involved in insulin and metabolism. Some of these interacting partners include AKT1, IGF1, TNF, PPARG, and INS. [R]

The data shows that GDF-8, along with two other genes called GRB14 and GPD1, may play a key role in regulating insulin sensitivity in the muscles of severely obese participants undergoing weight loss. Decreasing the levels of these genes could help improve metabolism and promote weight loss in obesity. The findings identify new gene targets that could potentially be manipulated to boost muscle insulin sensitivity during diet-induced weight reduction. [R]

Investigating potentials to modulate muscle hypertrophy for performance goals

So far, most research on blocking GDF8 (myostatin) has focused on potentially increasing muscle mass to improve physical functions like strength, walking ability, and movement. [R]

Studies in mice animal models show that inhibiting GDF-8 signaling specifically in muscle not only grows muscle mass but also potentially reduces overall body fat and possibly improves glucose metabolism. This makes sense because skeletal muscle comprises about one-third of total body weight and is key for clearing glucose from the bloodstream. [R]

One theory is that the complex regulatory system for controlling GDF-8 has evolved to allow local muscle growth in response to stimuli, while also enabling body-wide control over the balance of fat storage versus muscle growth. It seems that GDF-8’s fundamental role in governing this metabolic balance has been highly preserved through evolution. [R]

The results from the bimagrumab obesity/diabetes trial suggest the metabolic functions of muscle may be just as important as its mechanical functions when considering the health benefits of blocking GDF8. Potentially treating obesity and diabetes may therefore be major indications for GDF8 inhibitors. [R]

The functionally active recombinant human protein allows controlled in vitro and cell culture experiments. Proper handling techniques, like avoiding repeated freeze-thaws and verifying endotoxin levels, help maintain the reliability of results.

While further large-scale trials are still needed, recombinant GDF 8 remains a potential means for targeting muscle growth pathways in human test subjects, mouse models, rat models, and porcine models. Research in this area may someday yield clinical treatments for muscle disorders if proven safe and effective.

How Does GDF-8 Work?

Myostatin, or GDF 8, is a highly conserved, secreted growth differentiation factor protein that is a negative regulator of skeletal muscle growth. It is expressed specifically in skeletal muscle as a member of the transforming growth factor beta (TGF-β) superfamily. [R]

Myostatin binds to activin receptors on muscle cells, which starts signaling cascades inside the cell. These signals block muscle stem cells from multiplying and differentiating into mature muscle fibers during development. Ultimately this limits skeletal muscle hypertrophy. [R]

Scientists can add recombinant myostatin protein to human, mouse, rat, or pig tissue samples in research experiments to study myostatin inhibition. The active protein needs to be stored properly at the right temperature without freezing and thawing repeatedly. Before using the protein samples, tests should check for contaminants and confirm the presence of myostatin. [R] 

By understanding this muscle growth regulator better, further research may uncover ways to target myostatin to potentially control muscle growth. If proven safe and effective, this could someday help potentially treat muscular dystrophy or other diseases involving muscle loss. However, human clinical trials are still needed. [R]

Safety and Side Effects

As a potent inhibitor of muscle growth and regeneration, the use of GDF 8 could worsen muscle wasting conditions or damage if not properly tested and targeted. Overexpression studies also indicate possible detrimental effects on cardiac muscle by promoting fibrosis and cellular infiltration over time.  Additionally, the impacts of long-term myostatin inhibition on organismal aging have not been well characterized and could have unintended negative consequences later in life. Further research is still needed, especially large-scale clinical trials, to fully evaluate the safety profile and potential toxicity of manipulating GDF 8 signaling before any therapeutic use in human participants.

Frequently Asked Questions

 What is GDF-8?

GDF 8, also called myostatin, is a protein and growth factor that potentially inhibits muscle growth and regeneration. It has the potential to bind to receptors on muscle cells to block proteins that promote muscle protein synthesis.

How was GDF-8 discovered? 

In 1997, scientists discovered the gene for GDF 8 when studying a group of abnormally muscular mice models. These mice had mutations in the GDF 8 gene that prevented the production of functional myostatin protein leading to significant muscle hypertrophy.

What happens if GDF-8 is inhibited?

Inhibition of GDF 8, either genetically or using pharmaceutical approaches, leads to muscle hypertrophy and increased strength. Complete deficiency causes a “double muscling” phenotype in animal models. Strategies to block its activity are being researched to counteract muscle wasting disorders.

How can GDF-8 be inhibited?

Several different approaches are actively being researched to inhibit the activity and signaling of the growth differentiation factor 8 (GDF 8), also known as myostatin. One method involves blocking antibodies that specifically bind to GDF 8 and obstruct its ability to activate receptors on muscle cells. These antibodies physically get in the way and mask the parts of the protein needed for receptor binding. Another strategy employs natural proteins like follistatin, which may tightly bind to GDF 8 in circulation and prevent it from accessing muscle tissue to exert regulatory effects.

More advanced biotechnology methods are also being studied, including targeted gene therapies using technologies like RNA interference to directly knock down the expression of the myostatin gene itself within muscle cells. This reduces how much GDF-8 protein is produced overall. In addition, scientists are also screening and developing investigational compounds that can interfere with intracellular signaling pathways that operate downstream of the GDF 8 receptor inside muscle cells. 

Why Buy GDF-8 from BehemothLabz?

BehemothLabz is the best place to purchase GDF 8 online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee on GDF-8.

Summary

GDF-8, a myostatin inhibition marvel, serves as a negative regulator through activin type II receptors, unlocking a potential wealth of benefits for researchers exploring skeletal muscle dynamics. Our recombinant myostatin, an active protein, facilitates unparalleled insights into muscle growth and mass in diverse sample types, including rats, human subjects, mice, and porcine.

During clinical trials, GDF-8 shines by activating Smad signaling, contributing to embryonic development, and acting as a potential carrier protein critical for skeletal muscle growth. This growth differentiation factor 8 is a key player in cardiac muscle development, combating skeletal muscle atrophy, and presenting applications in human participants, mouse models, and rat models.

GDF-8 emerges as a closely related member of the TGF-beta family, serving as a potential regulator of skeletal muscle with applications in diverse research settings. Its potential is determined by its ability to control myoblast proliferation, making it a possible asset for scientists studying muscle hypertrophy, muscular dystrophy, and beyond.

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Strength	1mg