PE 22 28 (Peptide) – Product Details

PE 22-28 is a promising endogenous peptide with significant potential benefits. It is derived from naturally occurring peptide spadin, which inhibits the TREK-1 potassium channel. As a versatile peptide, it has been studied for various therapeutic applications, including mood regulation, anti-depressant, and neuroprotection, in subjects. 

With increased potency and stability, PE 22-28 has captured high attention, particularly in neurosciences. It is composed of 7 amino acids and is synthesized with the process known as solid-phase peptide synthesis. In addition, it has also been shown to have high stability and efficacy compared to its parent compound in research investigations. 

How Does PE 22-28 Work?

Generally, PE 22-28 works by inhibiting the TREK-1 channel with an IC50 value of 0.12 nM. This value is significantly lower than spadin, which indicates higher potency. TREK-1 channel is mostly expressed in the brain of subjects and is involved in mood regulation, memory, and cognition. Through inhibition of the channel, PE 22-28 has shown antidepressant properties in animal model research studies. 

The blocking of the channel modulates neuronal excitability and neurotransmitter release. This may lead to antidepressant effects. Similarly, studies have shown that PE-22-28 may enhance neurogenesis and synaptogenesis, contributing to its therapeutic potential in mood disorders.

Properties of PE 22-28

• Molecular formula: C35H55N11O9
• Synonyms: Gly-Val-Ser-Trp-Gly-Leu-Arg-OH
• IUPAC Name: glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine, acetate
• Molecular weight: 773.89 g/mol
• CAS Number: 1801959-12-5

Potential Benefits of PE 22-28?

PE 22-28 has been the subject of various research studies due to the following potential benefits in research studies.

• Mood Regulation:

TREK-1 (TWIK-related potassium channel-1) channel plays a significant role in neuronal excitability and mood regulation of research subjects. Through inhibition of this channel, PE 22-28 may stimulate the release of neurotransmitters associated with mood regulation. It has also been shown to promote neurogenesis and synaptogenesis in the hippocampus, a region in the brain involved in mood regulation. In addition to this, it may also enhance the proliferation of neuronal cells and the formation of new synaptic connections to stabilize mood. [1]

• Relieving Depression: 

Through mood regulation, PE 22-28 has also shown antidepressant abilities in research studies. The TREK-1 inhibition results in a more stable state of mind and an improvement in mood, which is great for potential depression treatment of test subjects. Preclinical studies have shown that a 4-day treatment with PE-22-28 may lead to enhanced neurogenesis in the hippocampus and increased synaptogenesis of subjects. This is evident by increased levels of the synaptic protein PSD-95. This action may relieve depression by improving the mood of participants. [2]

• Reducing Inflammation:

Emerging research has shown that PE-22-28 may also exhibit anti-inflammatory effects. It may modulate neuroinflammation by interacting with specific receptors or signaling pathways involved in the inflammatory responses. This modulation may decrease pro-inflammatory cytokines, leading to reduced inflammation in subjects. [2]

• Muscle Function: 

According to research studies, the TREK-1 potassium channel plays a role in muscle physiology. Its potential activation may lead to muscle relaxation while blocking causes muscles to contract. As PE-22-28 inhibits TREK-1, it has been shown to influence muscle function by promoting increased contractility. [3]

• Neuroprotective: 

PE 22-28 may exhibit neuroprotective properties through several mechanisms. With inhibition of TREK-1 channels, reduction of apoptotic cell death, and enhancement of neurogenesis and synaptogenesis, PE 22-28 may act as a neuroprotective agent. As a neuroprotective agent, It has been studied for its potential use in neurodegenerative diseases and conditions associated with neuronal damage. [3]

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The blend of these qualities can’t be found anywhere else. So, avail yourself of the opportunity by ordering our PE 22-28 online now and begin your research journey. 

Frequently Asked Questions (FAQs) 

Does PE 22-28 peptide therapy work?

Yes, as a TREK-1 inhibitor, PE 22-28 peptide therapy has shown promising work in research investigations. It has been shown to improve mood and exhibit anti-depressant effects in test participants. 

What is the purpose of PE 22-28 peptides?

The purpose of PE 22-28 peptides is to offer antidepressant, neuroprotective, and cognitive-enhancing effects in clinical studies. It may promote neurogenesis and synaptogenesis to support brain health.

What is the best place to buy PE 22-28 online?

The best place to buy PE 22-28 online is BehemothLabz. It offers quality and pure PE 22-28 for sale at an affordable price with the best shipping services. 

Is PE 22-28 legal and safe?

Yes, PE 22-28 is generally considered legal and safe for research purposes. However, its human consumption is not yet approved. 

What are the side effects of PE 22-28 on research subjects?

Although PE 22-28 has shown potential benefits without any adverse effects, some subjects have reported mild side effects, including injection site reactions, such as pain, swelling, redness, itching, and allergies. 

References 

1. Series, Web. “Serotonin Transmission and PE-22-28 Research.”
2. Djillani, Alaeddine, et al. “Shortened spadin analogs display better TREK-1 inhibition, in vivo stability and antidepressant activity.” Frontiers in Pharmacology 8 (2017): 643.
3. Djillani, Alaeddine, et al.. “Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin.” Pharmacology & Therapeutics 194 (2019): 185-198.

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