RAD140 VS LGD4033: Side By Side Comparison

In the research community, RAD140 and LGD-4033 are two important SARMs that have attracted attention. While they share potential, they differ in many respects. These differences yield diverse results in preclinical models. But what are these differences, and how do they differ from each other? Are they similar in some ways? These are the questions we will address in this blog.

Read this blog thoroughly and understand the nature of RAD140 Vs LGD4033.

What is RAD140?

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RAD140 is a synthetic SARM (Selective Androgen Receptor Modulator). It is also known as Testolone. It is currently under preclinical trials. Researchers are investigating it for various applications in preclinical models.

In preclinical studies, RAD140 has altered the patterns underlying muscle growth and skeletal health. Besides, it has also been shown to have the potential to influence fat metabolism patterns in preclinical models. These impacts were observed without altering the pathways related to the prostate gland due to its selective nature.

What is LGD-4033 (Ligandrol)?

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Ligandrol is a synthetic SARM (Selective Androgen Receptor Modulator). It is also known as LGD-4033 in the research community. This compound is currently being investigated for its therapeutic potential in preclinical settings. Researchers are interested in understanding how LGD-4033 stimulates anabolic pathways in preclinical settings.

In early studies, researchers observed that it affected the patterns of muscle growth, bone health, and the repair and regeneration of muscle tissue in preclinical models. In other studies, it has also impacted the pathways of fat metabolism.

Mechanism of Action

RAD140 and Ligandrol have shown similar mechanisms of action in preclinical studies. When administered to preclinical models, these compounds may bind with androgen receptors in muscle and bone tissue. This binding may trigger anabolic signaling pathways in preclinical models. Some of these activities are related to muscle hypertrophy, bone integrity, and fat metabolism in preclinical models.

Side-By-Side Comparison of RAD140 and Ligandrol (LGD-4033)

RAD140 and Ligandrol are synthetic SARMs. They are investigated for similar purposes in preclinical settings. Despite being investigated for similar purposes, they share both similarities and differences. Here is a detailed overview of their key similarities and differences:

Key Similarities

Key Similarities Between RAD140 and Ligandrol (LGD-4033)
Similarities	RAD140	Ligandrol (LGD-4033)
Both are SARMs	RAD140 is a synthetic SARM (Selective Androgen Receptor Modulator).	Ligandrol is also a synthetic SARM (Selective Androgen Receptor Modulator).
Similar Mechanism of Action	RAD140 binds androgen receptors in muscle and bone tissues in preclinical models. This binding activates anabolic pathways in preclinical models.	Similarly, Ligandrol also binds androgen receptors in muscle and bone tissues in preclinical models. This binding stimulates anabolic signaling pathways in preclinical models.
Similar Potential	RAD140 has the potential to stimulate anabolic pathways in preclinical models. These are mostly related to muscle hypertrophy, bone health, and fat metabolism in preclinical settings.	Ligandrol also has the potential to stimulate parameters related to anabolic activity in preclinical models. This stimulation may result in muscle hypertrophy, improved skeletal health, and reduced adipose tissue in preclinical models.
Used for Similar Purposes	RAD140 is being investigated to understand how it triggers pathways involved in anabolic activity in preclinical models.	In a similar vein, Ligandrol has also been investigated to understand its effects on anabolic pathways in preclinical models.
Similar Legal Status	RAD140 is currently on the FDA’s prohibited list. It is used only for laboratory research.	Ligandrol is also prohibited for human consumption. It is only used for laboratory experiments.

Key Differences

Key Differences Between RAD140 and Ligandrol (LGD-4033)
Similarities	RAD140	Ligandrol (LGD-4033)
Chemical Structure	RAD140 belongs to the benzimidazole class of compounds.	Ligandrol belongs to the aryl-propionamide class of compounds.
Half-Life	RAD140 has a half-life of up to two days in preclinical models.	Ligandrol has a half-life of up to a day in preclinical models.
Anabolic Impacts	In preclinical studies, RAD140 has shown greater potency in demonstrating anabolic effects.	Ligandrol has been shown to exhibit moderate potency to influence anabolic pathways in preclinical models.
Hormonal Suppression	RAD140 may lead to high suppression or hormonal fluctuation in preclinical models.	Ligandrol may lead to moderate suppression or hormonal fluctuation in preclinical models.

Similar Research Applications of RAD140 and LGD-4033

Here are the identical research applications of RAD140 and LGD-4033 in preclinical settings: 

• Both RAD140 and LGD-4033 have been shown to modulate pathways involved in muscle growth in preclinical models. 
• These compounds may also influence patterns of lean muscle mass in preclinical models. 
• They may also influence parameters of fat metabolism in preclinical settings. 
• They may also impact the pathways linked to skeletal health in preclinical models. 

Associated Side Effects of RAD140 and Ligandrol (LGD-4033)

The associated side effects of RAD140 and Ligandrol are as follows: 

Side Effects of RAD140	Side Effects of Ligandrol
Nausea	dizziness
Headache	irritation
Hormonal fluctuation	Appetite fluctuation
dizziness	Liver toxicity
Fatigue	Headache

Note: These side effects were observed during preclinical studies on the compounds. Therefore, they may differ from subject to subject and depend on various underlying factors. 

Regulatory Status

Regarding the regulatory status of these compounds, they are currently on the FDA’s prohibited list. Therefore, they are not allowed for human use. However, researchers may use them for laboratory research purposes. 

Final Thought

RAD140 and Ligandrol (LGD-4033) are two research-based SARMs. They are being investigated for their potential to influence anabolic pathways in preclinical models. These pathways are related to muscle growth, fat metabolism, and skeletal health in preclinical settings. In addition to their potential impacts, these compounds differ in chemical structure and potency. Regarding their regulatory status, they are currently on the FDA’s prohibited list for human consumption. 

Frequently Asked Questions

Where can I buy RAD140 and Ligandrol online?

You can buy RAD140 and Ligandrol online from BehemothLabz.

What is RAD140 used for in laboratory studies?

RAD140 is used in laboratory studies to understand its effects on patterns linked to muscle hypertrophy, skeletal health, and fat metabolism in preclinical models.

Is RAD140 toxic to the liver of preclinical models?

In preclinical studies, RAD140 may have a slight effect on liver function. However, the extent of liver impacts differs from subject to subject.

Does RAD140 influence estrogen in laboratory studies?

No, RAD140 may not influence estrogen pathways in preclinical models during laboratory studies.

How long does LGD-4033 stay in the system?

LGD-4033 may be detectable in preclinical models for up to 3 weeks.

Does LGD-4033 affect hormones in preclinical models?

In preclinical studies, LGD-4033 may have moderate effects on hormonal patterns.

References:

1. Fragkaki, Argyro G., et al. “Human in vivo metabolism study of LGD‐4033.” Drug testing and analysis 10.11-12 (2018): 1635-1645.
2. Wagener, Felicitas, et al. “Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes.” Analytical and bioanalytical chemistry 414.2 (2022): 1151-1162.
3. Judd, Sarah, and How Does LGD. “Ligandrol (LGD-4033)| Complete Profile, Dosage, Results, and Other Relevant Information.”
4. Yu, Ziyang, et al. “Selective androgen receptor modulator RAD140 inhibits the growth of androgen/estrogen receptor–positive breast cancer models with a distinct mechanism of action.” Clinical Cancer Research 23.24 (2017): 7608-7620.
5. LoRusso, Patricia, et al. “A first-in-human phase 1 study of a novel selective androgen receptor modulator (sarm), rad140, in er+/her2-metastatic breast cancer.” Clinical breast cancer 22.1 (2022): 67-77.
6. Jayaraman, Anusha, et al. “Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.” Endocrinology 155.4 (2014): 1398-1406.