Semax vs Selank: A Detailed Comparison

Comparison of any two peptides is essential to understand and differentiate between them. It may also make it easy for researchers to select between them. In this regard, we are comparing Semax vs Selank peptides. In this comparison blog, we will address their nature, mechanisms of action, similarities, and differences between them.

Read this blog and gain insight into these peptides!

What is Semax?

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Semax is a synthetic compound. It has been formulated as an analog of a segment of the naturally occurring Adrenocorticotropic Hormone (ACTH) (4-10). The ACTH is naturally produced and is responsible for dealing with patterns linked with stress, anxiety, and depression in research subjects. Similarly, this synthetically formulated Semax compound has also been utilized to influence similar pathways in research subjects.

These pathways are associated with mental stress, depression, anxiety, and post-traumatic disorders in various laboratory models. Additionally, this is also used in laboratory studies to influence cognitive abilities, focus, and alertness of research models.

How Does Semax Work?

According to preclinical trials on animal models, Semax peptide works in multiple ways. To explain, it may work by modulating Brain-Derived Neurotrophic Factor (BDNF). BDNFs are proteins responsible for supporting, growing, and protecting neurons in animal models during studies. Similarly, Semax peptide may also influence dopaminergic and serotonergic pathways. By influencing these pathways, Semax may exhibit anti-stress and anti-depression properties in laboratory models.

Semax may also demonstrate antioxidant properties, protecting neurons in animal models from oxidative stress.

What is Selank?

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Selank is also a synthetic compound. It has been formulated as an analog of the naturally occurring compound tuftsin, an immunostimulatory compound. The Selank compound has an addition of three extra amino acid molecules compared to tuftsin. These extra amino acid molecules extend the half-life and efficacy of the selank compound in laboratory studies on animal models.

In addition to half-life, these three amino acid sequences may also influence the secretion of dopamine and serotonin in laboratory models. This influence may also modulate focus, learning, and attention in animal models during laboratory studies.

How Does Selank Work?

There is no single working mechanism of the Selank peptide. Its working mechanism influences multifaceted pathways in animal models during studies. According to studies, Selank peptide may demonstrate serotonergic and dopaminergic properties in laboratory models. Through these properties, Selank may exhibit anti-depression and anti-anxiety properties in models during trials. Additionally, Selank may also bind with GABA receptors, creating relaxation effects without causing drowsiness in animal models during studies.

Similarly, Selank may also show anti-inflammatory properties, managing inflammation and depression, as shown in clinical trials.

Similarities Between Semax and Selank Compounds

Semax and Selank peptides share some similarities. Here is the list of similarities between them:

• Belong to Peptide Family: 

Both of them (Semax and Selank) belong to the same peptide family. They both are made of small chains of amino acid molecules, just like other naturally occurring peptides.

• Similar Potential Nootropic Effects: 

These compounds show similar nootropic effects during clinical studies in research subjects. Nootropic effects refer to improving brain function, which includes learning, memory, focus, and mental clarity in animal models during studies. 

• Similar Potential Anxiolytic Effects: 

These peptides also show anxiolytic properties in laboratory models during clinical trials. For anxiolytic effects, these compounds influence the pathways linked with serotonergic and dopaminergic systems. Through influencing these pathways, both of them exhibit anti-depression and anti-stress properties. 

• Similar Routes Of Administration In Research Studies: 

Both are used either through the nasal cavity or subcutaneously in animal models. While passing through the nasal cavity of animal models, it is used in spray form. On the other hand, it is used inside an injection to administer subcutaneously in laboratory models. 

• Similar Potential Neuroprotective Properties: 

These compounds also exhibit neuroprotective properties in laboratory models during clinical trials. For neuroprotective effects, these compounds may influence pathways associated with BDNF, GABA receptors, and anti-inflammatory mechanisms in models. Through these pathways, the neurons are supported, grow, and protected during studies in models. 

Key Differences Between Semax and Selank

Despite influencing similar pathways, these compounds also share differences. Here is the list of these differences between them:

• Different Mechanisms of Action:

Semax peptide modulates BDNF and other neurotransmitter pathways in animal models. Through this modulation, Semax peptide may demonstrate anxiolytic and cognitive enhancement properties. On the other hand, Selank peptide may bind with and modulate GABA receptors, protecting neurons from oxidative stress and damage. 

• Different Primary Clinical Use:

These peptides have different primary clinical uses. Semax is used for anti-depression, anti-stress, and neuroprotective properties in laboratory models during studies. On the other hand, the primary use of Selank peptide in research studies is to modulate pathways linked with anti-inflammation and the immune system of test models. 

• Different Duration of Effects: 

They both have different durations of effects. Semax is considered to have a shorter duration of effects in laboratory studies. Whereas, Selank peptide may exhibit properties for a longer period in laboratory models. 

Which One is Better: Semax and Selank

No parameters are showing the best peptide between Semax and Selank. Both of them are good in their own ways. For instance, researchers utilize Semax peptide while exploring pathways linked with stress, anxiety, and depression.

On the other hand, they use Selank while exploring the patterns linked with the immune system, inflammation, and depression. In short, the selection between them depends on the goals and objectives of research studies and the health condition of the models used.

Final Thoughts

Semax and Selank are the two synthetic peptides currently under investigational trials. They share similarities as well as differences. Belonging to the same peptide group and exhibiting anxiolytic effects in animal models are some of their similarities. On the other hand, they differ in their structure and mechanism of working. Regarding the best choice between them, it depends on the research goals, objectives, and underlying health conditions of laboratory models.

Frequently Asked Questions (FAQs)

What is the best place to buy Semax and Selank online?

The best place to buy Semax and Selank online is BehemothLabz. At BehemothLabz, all products are developed to meet the industrial needs and requirements of research studies. Moreover, the prices of their products are reasonable and within the buying range.

Is Semax FDA-approved?

No, Semax is not FDA-approved for human use, but it may be used for research purposes.

What are the benefits of Semax for research models during clinical studies?

The benefits of Semax for clinical models are to influence the pathways linked with anxiolytic effects and neuroprotective properties. Through this influence, semax peptides may demonstrate anti-stress and anti-depression properties besides protecting neurons from oxidative stress.

What is Selank peptide used for in laboratory studies?

Selank peptide may be used to demonstrate anti-depression, anti-stress, and anti-inflammatory properties in laboratory studies. Through these effects, it may also protect neurons from inflammation in clinical models.

Are peptides safe for research studies?

Yes, peptides are safe for laboratory use and research studies. They may not cause severe side effects for research models, except for a few mild ones. Furthermore, to make them safer, researchers are advised to follow recommended guidelines and research protocols.

References:

1. Koroleva, S. V., and N. F. Mjasoedov. “Physiological effects of Selank and its fragments.” Biology Bulletin 46.4 (2019): 407-414.
2. Vyunova, Tatiana V., et al. “Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity.” Protein and Peptide Letters 25.10 (2018): 914-923.
3. Koroleva, S. V., and N. F. Myasoedov. “Semax as a universal drug for therapy and research.” Biology Bulletin 45.6 (2018): 589-600.
4. Dolotov, Oleg V., et al. “Semax, an analog of ACTH (4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.” Brain research 1117.1 (2006): 54-60.