LGD 4033 vs RAD 140: The Ultimate Comparison

The comparison between SARMs offers plenty to unpack. As highly investigational compounds, LGD 4033 and RAD 140 are two names that often dominate this comparison in the world of selective androgen receptor modulators (SARMs).

Although these two SARMs may offer several benefits such as muscle growth, boosting strength, and enhancing fat loss, they differ in terms of potency, side effects, and specific use cases. Understanding these differences is key to optimal and safe results in research studies. 

This guide provides comprehensive details into the specifics of each, comparing their effectiveness, safety profiles, side effects, and more. Read on to uncover the clear picture.

Understanding the LGD 4033 & RAD 140

LGD 4033, also known as Ligandrol, is a potent SARM. Being effective at low dosages, it is highly researched and currently undergoing clinical phase 2 trials. As a prospective SARM, LGD 4033 may increase lean muscle mass, strength, and bone mineral density in test subjects. This SARM has strong anabolic effects and has been studied for treating health conditions like muscle-wasting diseases. 

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Conversely, RAD 140 is popularly studied for enhancing performance and strength by many fitness enthusiasts and bodybuilders. Even a small dose has shown significant results in research subjects. Like Ligandrol, it has lower androgenic and higher anabolic effects. Studies show that it may increase muscle mass, improve bone health, and enhance strength. With fewer unwanted effects, this SARM is also investigated for treating Alzheimer’s disease in mice. 

How do LGD 4033 and RAD 140 Work?

Both SARMs have similar mechanisms of action. LGD 4033 and RAD 140 work by selectively targeting the androgen receptors in muscles and bones. Once attached, they increase anabolic activities in muscles and may improve lean muscle mass. Similarly, Testolone and Ligandrol may also improve bone health and enhance strength. While they act alike in the subject body, there are still significant differences between LGD 4033 and RAD 140. 

LGD 4033 Vs. RAD 140: A Comparative Analysis

The following differences in uses, benefits, and side effects set LGD 4033 and RAD 140 apart. 

1. Uses 

Both LGD 4033 and RAD 140 are used in research studies. Ligandrol is generally used to study its benefits in increasing muscle mass in research subjects. Due to its anabolic effects, it is also frequently used for its potential treatment in muscle loss diseases. Being a potent SARM, it has also been used to study its positive impacts on bone density. 

While RAD 140 is used to study its muscle-building and strength-increasing properties. It is also used as a neuroprotective SARM in rat model studies to treat Alzheimer’s disease. 

2. Benefits 

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LGD 4033 is reported to show potential benefits in a moderate and controlled way than RAD 140.  Some major benefits of LGD 4033 that make it different from other SARMs include:

• Lean muscle mass: It may help increase lean muscle mass in subjects. A clinical study shows a daily dose of 1 mg of LGD-4033 over 21 days may result in an average increase of lean body mass by 1.2 kg (about 2.6 pounds).
• Bone density: Ligandrol has been shown to improve bone health particularly bone mineral density (BMD). Rat model studies have proven that after 12 weeks of administering LGD-4033 at doses as low as 0.03 mg/kg/day in cortical bone and 0.3 mg/kg/day in cancellous bone may significantly improve BMD. 
• Physical function and strength: With anabolic effects, it has also been proven to have strength-enhancement properties as shown in research studies. A study shows that it may increase about 68.3 N strength when participants received LGD 4033 doses (0.1 mg, 0.3 mg, or 1.0 mg) over a 21-days. 

In contrast, RAD 140 has proven to give results faster than LGD 4033. Some of its potential benefits are given as follows. 

• Lean muscle mass: Testolone has been shown to increase lean muscle mass in research subjects when quick results are required. In a study conducted on young intact male rats, RAD140 may increase skeletal muscle mass when administered over 11 days in subjects. 
• Improve Strength: RAD 140 may improve strength in research subjects. It may boost body energy levels to promote the strength of the subject body. 
• Fat loss: Besides its anabolic effects, RAD 140 has been extensively studied for its potential to reduce fat in subjects. Test subjects have experienced a reduction of approximately 5% in body fat over 8 weeks during a research study.

3. Side Effects 

Both LGD 4033 and RAD 140 SARMs are generally considered safe to use in research studies. However, RAD 140, being potent, is associated with more side effects than LGD 4033. They may be associated with testosterone suppression in subjects and Testolone may be an aggressive suppressor due to its potency. Some other side effects that these two SARMs may cause in subjects include mood change, acne, nausea, and liver stress. 

4. Half-life 

Most clinical studies have shown that RAD 140 has an average half-life of 40-60 hours in subjects. While LGD 4033 has a half-life of 24-36 hours in research participants. This shows that RAD 140 may be a better option for studies that require frequent dosing. 

5. Before and After Results 

RAD 140 wins when it comes to showing faster results in research studies. It may give quicker muscle gain than Ligandrol in subjects. Similarly, being potent, Testolone (RD 140) may have a higher rate of increasing power and energy in test participants than LGD 4033. 

Which Option is Better?

The better option between RAD 140 and LGD 4033 depends on study needs, goals, objectives, and preferences. If you need potent SARM to increase muscles, lose fats, and give strength in research studies, the better option is Testolone. On the other hand, Ligandrol is a mild SARM with moderate action and fewer side effects than RAD 140. 

Conclusion 

The two SARMs LGD 4033 and RAD 140 are popular in fitness research. They may provide muscle-building and strength improvement benefits in subjects. With extensive research, they are also used in treatment studies of health conditions such as muscle wasting diseases. Whether you are a bodybuilder or a fitness enthusiast, studying Testolone vs. LGD 4033 for muscle-gaining properties is essential for getting optimal results in research. 

FAQs

What is the best place to buy LGD 4033 and RAD 140 online?

The best place to buy LGD 4033 and RAD 140 online is Behemoth Labz. It prioritizes product purity and quality with 100% trusted customer service. To ensure effective and optimal results in studies, considering products of Behemoth Labz is paramount. Besides providing high-quality products, its products also maintain reliable research results. 

Are Ligandrol and Testolone legal? 

Yes, Ligandrol and Testolone are legal for research studies. These two SARMs are highly studied for potential benefits of muscle gain. 

Which one is highly potent between LGD 4033 and RAD 140 for research subjects?

RAD 140 is more potent than LGD 4033 and may provide faster results in research investigations. 

Do LGD 4033 and RAD 140 lower testosterone in research subjects?

Yes, LGD 4033 and RAD 140 may lower testosterone. However, it may vary and depend on the subject’s health status and dosage. 

Is post-cycle therapy (PCT) necessary for LGD-4033 and RAD-140?

Yes, post-cycle therapy (PCT) is necessary for LGD 4033 and RAD 140 to maintain natural testosterone levels in test participants. However, it depends on the study design and dosage. 

References

1. Basaria, Shehzad, et al. “The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.” Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 68.1 (2013): 87-95.
2. Loss, Fat. “RAD-140 Review: Benefits, Dosage & Side Effects.”
3. Barbara, Mary, Sadhna Dhingra, and Ayse L. Mindikoglu. “Drug-induced liver injury associated with Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033).” ACG case reports journal 7.6 (2020): e00409.