Avanafil – Product Details

Avanafil, also known as Stendra, is an experimental drug that belongs to the class of phosphodiesterase type 5 inhibitors (PDE5 inhibitors). This formulation is being studied for its alleged ability to treat erectile dysfunction. Studies show that avanafil works by increasing blood flow to the penis during sexual stimulation, allowing for a firmer and longer-lasting erection.

While Avanafil has the potential to treat erectile dysfunction, it is important to note that it should be used for research purposes only. Buy Stendra online for your research studies. Additionally, it is not an approved supplement to improve sexual performance or enhance libido.

Avanafil cannot be aligned with other erectile dysfunction medications (aka ed meds) because we need further studies to understand its complete mechanisms of action. Behemoth Labz sells avanafil for research purposes alone.

• CAS Number: 330784-47-9
• Molar Mass: 483.95 g/mol
• Chemical Formula: C23H26ClN7O3
• IUPAC Name: (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• Also known by Synonyms: Stendra, Spedra

What is Avanafil?

Avanafil is a potential medication that could belong to the class of erectile dysfunction medications known as phosphodiesterase type 5 (PDE5) inhibitors. It is currently thought that avanafil works by boosting blood flow to the penis during sexual activity, which aids in the production and maintenance of an erection.

Avanafil is specifically being tested to improve erectile function in men and is used by many researchers. Based on its performance in laboratory studies, avanafil has a rapid onset of action, with effects seen as early as 15 minutes after ingestion.

Possible Uses of Avanafil

May Potentially Address Erectile Dysfunction

Avanafil is primarily being studied to treat erectile dysfunction in men. A randomized, double-blind study found that avanafil was effective in improving erectile function in men with diabetes mellitus. [R]

Of the 1378 test subjects screened, 390 were randomized to therapy, with 129 getting 100 mg avanafil, 131 receiving 200 mg avanafil, and 130 receiving a placebo. Both the 100-mg and 200-mg dosages of avanafil were substantially more efficacious than the placebo for all three coprimary end goals over the 12-week treatment period. [R]

May Potentially Improve Premature Ejaculation

Avanafil has been shown to improve ejaculatory control in men with premature ejaculation. A study found that avanafil improved ejaculatory control and sexual satisfaction in male test subjects experiencing premature ejaculation. [R]

Raynaud’s Phenomenon

Avanafil has been studied as a potential treatment for Raynaud’s phenomenon, a condition characterized by decreased blood flow to the fingers and toes. A small clinical trial found that avanafil improved digital blood flow and reduced the frequency and duration of Raynaud’s attacks in patients with Raynaud’s phenomenon. [R]

Pulmonary Arterial Hypertension

Avanafil has been investigated as a potential treatment for pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the lungs. A preclinical study found that avanafil improved pulmonary hemodynamics and exercise capacity in a rat model of PAH. [R]

How Does Avanafil Works

Avanafil is a research chemical that is being studied because it demonstrates the potential to address erectile dysfunction (ED) in men. It works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells lining the blood vessels of the penis. By inhibiting PDE5, avanafil helps to increase the levels of cGMP, leading to the relaxation of the smooth muscle cells and increased blood flow to the penis during sexual stimulation. This increased blood flow can lead to an erection that can last for up to six hours.

Avanafil’s active ingredient is similar to that of other ED medications, such as sildenafil (Viagra), but it is more selective in its action, meaning that it primarily targets PDE5 and has less of an effect on other phosphodiesterase enzymes. This selectivity can lead to fewer side effects and faster onset of action compared to other ED medications.

Overall, avanafil’s mechanism of action involves improving blood flow to the penis by relaxing the smooth muscle cells in the blood vessels, leading to improved erectile function in men with ED.

Safety and Side Effects

The use of avanafil can be generally safe and well-tolerated, but like any medication, it can cause serious side effects. The most common side effects of avanafil include headache, chest pain, facial flushing, nasal congestion, and back pain.

Other less common side effects include dizziness, upset stomach, and blurred vision. It is important to note that avanafil can interact with other medications, such as nitrate medication.

It is recommended to consult with a doctor before starting avanafil or any other medication.

Frequently Asked Questions

How does Avanafil work?

When combined with sexual stimulation, avanafil works by boosting blood flow to the penis, allowing a male test subject to attain and maintain an erection.

Is Avanafil effective with other medications?

Avanafil can interact with certain medications, such as nitrates. The effect of such a situation could lead to a decrease in blood pressure or sudden vision loss.

Can Avanafil cause priapism?

Avanafil may cause priapism, a potentially dangerous adverse effect. This is a severe erection that can continue for several hours. It is a possible adverse effect of all PDE5 inhibitors that, if left untreated, can cause irreversible damage to the tissue of the penis. [R]

How does Avanafil affect blood pressure?

Because avanafil demonstrates similar mechanisms of action with PDE5 inhibitors, it is very likely that it could likely lead to low blood pressure.

The majority of PDE5 inhibitors’ effects are related to vascular smooth muscle relaxation and vasodilation. When this occurs in the systemic circulation, it has the ability to lower blood pressure. This drop in blood pressure might result in reflex cardiac stimulation, increased cardiac output, and higher heart rate. [R]

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Summary

Avanafil is an experimental chemical formulation being studied for its potential ED medication. Current laboratory findings suggest that avanafil could foster a faster onset of action, longer duration of effect, and improved sexual function. Additionally, avanafil may have potential benefits in the treatment of Peyronie’s disease and other prostate problems.

Although avanafil has a similar mechanism of action to other ED medications, it may have fewer side effects and be better tolerated. However, it is important to note that avanafil may carry a higher risk in certain populations, such as those with pre-existing medical conditions or those taking certain medications.