GHRP-6 is a synthetic (GH) growth hormone secretagogue. A small-scale clinical trial reported that patients with primary hypothyroidism had a significantly higher GH release after GHRP-6 injection than when they were administered GH-releasing hormone (GHRH).
Preclinical studies have shown that GHRP-6 elicits a dose-dependent natural growth hormone release in vivo and in vitro. This growth hormone-releasing peptide has also been reported to attenuate cardiac dysfunction.
When administered alongside insulin, GHRP-6 promoted weight gain and body fat.
Behemoth Labz sells GHRP-6 for laboratory and research use only.
CAS Number is 87616-84-0
Molar Mass is 873.014 g/mol
It has a chemical formula of C46H56N12O6
IUPAC’s name is L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-lysinamide
Also known by synonyms as GHRP-6, GHRP.
What is GHRP-6?
GHRP-6 is an acronym for Growth hormone-releasing peptide-6. It is a synthetic hexapeptide (six amino acids) believed to stimulate growth hormone secretion by pituitary somatotrophs. It has non-growth hormone-related cytoprotective effects such as neuroprotection, cardioprotection, anti-inflammatory effects, and hepatoprotection.
Several clinical and preclinical studies have established that GHRP-6 significantly increases the body’s endogenous GH secretion. Yet large-scale studies are still needed to support this claim.
GHRP-6 is a ghrelin receptor agonist, meaning it mimics the actions of ghrelin receptors in the body. Ghrelin, aka “hunger hormone,” regulates appetite in the body.
Its other functions include stimulating GH secretion from the anterior pituitary and protecting cardiovascular health. [R]
GHRP-6 remains the first synthetic peptide to elicit GH release in vivo and in vitro. Other manufactured peptides that are now being investigated for their effects on GH release, such asHexarelin andGHRP-2, were only synthesized after GHRP-6 had proven its efficacy. [R]
Multiple studies have been conducted on GHRP-6 since it was first synthesized. They have shown that this GH secretagogue has a relatively long half-life of 1.4 to 2.6 hours.
Behemoth Labz sells GHRP-6 for clinical science use and not for human consumption. [R]
Possible Uses of GHRP-6 Peptide
What follows is a summary of the existing research on GHRP-6. The information presented in this section is for educational purposes only. It doesn’t constitute medical advice. Behemoth Labz sells GHRP-6 for scientific and laboratory research purposes only.
GHRP-6 Peptide and Sleep
Sleep occurs in four stages: light sleep (N1), more profound sleep (N2), deepest non-REM sleep (N3), and REM. Stage two sleep (N2) makes up 45% of total sleep time. [R]
In laboratory experimentation done in healthy males, GHRP-6 treatment improved the quality of stage 2 sleep. The patients given this research chemical spent more time in N2 than placebo patients. They also exhibited an insignificant trend of decreased wakefulness. [R]
GHRP-6 Peptide and Memory Formation
For some time, researchers have been looking into the role of physical activity in learning and memory formation.
Though the precise mechanism has remained a mystery, there has always been reason to believe that physical activity improves cognition and learning, mainly when exercise is performed immediately after a learning task.
Initially, the benefit of exercise on cognition was attributed to increased blood flow and vague mentions of growth hormones. (GH).
Studies in animal models have revealed that GHRP-6 can help to solidify newly formed memories and convert short-term memories into long-term storage, which helps to explain why GH may be an essential factor in memory formation. [R]
There is also compelling evidence that ghrelin/GHRP-6 plays a role in spatial learning tasks.
This suggests that the cognitive benefits of exercise may be mediated by growth hormone secretagogues such as ghrelin and that the GH effect may be indirect and, perhaps, secondary to these peptides. [R]
GHRP-6 Peptide and Heart Health
In a mice model of acute myocardial infarction (heart attack), GHRP-6 treatment boosted heart health by decreasing reactive oxygen species (ROS) and preserving antioxidant defense systems. [R]
GHRP-6 also prevented ischemic-induced death in dogs with chronic dilated myopathy. Though conducted on animals, this study might hold huge significance for humans.
Chronic dilated myopathy (a type of heart muscle disease) is the most common cardiovascular disease. [R]
GHRP-6 Peptide May Protect Brain Tissue
Animal stroke models are being used to investigate Growth Hormone Releasing Peptide 6’s ability to protect neurons and other cells in the central nervous system from the effects of poor blood supply.
There’s scientific research done on the dose-response relationship and therapeutic time window in global brain ischaemia. It turns out that GHRP-6 protects brain tissue during acute stroke and can also rescue memory deficits after stroke therapy. [R]
Ghrelin and its analogs appear to inhibit apoptosis (programmed cell death) and reduce inflammation in the brain, protecting neurons from both their genetic programming and the surrounding environment following stroke. [R]
GHRP-6 Peptide and Stress Ulcers
Stress ulcers affect the upper gastrointestinal tract (stomach, esophagus, duodenum). They develop after trauma, shock, and sepsis and can worsen if not treated.
According to a preclinical study, GHRP-6 exerts a protective effect on gastric ulcers. Drawing on this effect, the researchers hypothesized that GHRP-6 suggests a possible therapeutic clinical application in treating a stress-related gastric injury. [R]
GHRP-6 Peptide and Obesity
In a mouse model of postmenopausal obesity, GHRP-6 decreased body weight, blood glucose levels, and insulin and leptin levels. All these effects pointed to its anti-obesity effects. [R]
It was noted that GHRP-6 induced the above effects by decreasing the mice’s food intake. That was especially true for animals who were on standard or high-fat diets.
All in all, ghrelin agonists may help individuals with high body fat or obesity.
GHRP-6 Peptide and Wound Healing
By reducing programmed cell death, GHRP-6 improves the survival of many different types of cells. Growth hormone-releasing peptide also interacts with the CD36 receptor, which has been shown to promote blood vessel growth in wounds. [R]
An animal study reported that GHRP-6 expedited the closure of excisional full-thickness wounds. It also attenuated wound inflammation as well as improved wound esthetic. [R]
This experiment indicated three possible pathways through which GHRP-6 expedites the healing process. These include the attenuation of immunoinflammatory mediators, their effector cells, and the reduction of the expression of fibrotic cytokines. [R]
How Does GHRP-6 Work?
GHRP-6 peptide stimulates GH secretion by acting on somatotrophs, cells in the anterior pituitary glands that release growth hormone. This action appears to be mediated by three distinct mechanisms, which are:
Increased Ca2+ inflow through calcium channels [R]
While it is known for increasing GH secretion, recent research indicates that GHRP-6 may also stimulate the secretion of adrenocorticotropic (ACTH) and prolactin hormones.
Both these hormones are produced by your pituitary gland but perform different functions. [R]
Safety and Side Effects
A phase 1 clinical trial reported that GHRP-6 was safe and tolerable under the conditions studied. The study involved 18 healthy men aged between 18 and 35. It was noted that GHRP-6’s administration didn’t generate harmful oxidative stress. [R]
Frequently Asked Questions
What is natural growth hormone-release peptide?
Growth hormone-releasing peptides (GHRPs) are synthetic peptides that stimulate gh release from the pituitary gland. Research on peptide sciences shows that GHRPs act on somatotrophs to increase GH secretion.
Is Growth Hormone Releasing Peptide (GHRP) FDA-approved?
The FDA is yet to approve any growth hormone-releasing peptide.
Are GHRP 6 peptides safe?
CJC-1295 and GHRP-6 peptides have been shown to be safe and free of potentially harmful side effects. However, it may negatively affect some subjects, just like other research peptides.
Where Can You Buy The Best GHRP-6 for Sale
Behemoth Labz is the best place to buy GHRP-6 online.
We have been around since 2014, supplying the highest-quality research chemicals money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee on GHRP-6.
GHRP-6 is an artificial peptide hormone that stimulates growth hormone production. It inhibits GH secretion by blocking the hormone somatostatin. Somatostatin regulates the release of growth hormones throughout the body.
As a result of using the synthetic variation, one can expect an increase in lean muscle mass, a decrease in body fat, and improved stamina. According to research, GHRP-6 increases appetite by catalyzing ghrelin secretion in the stomach.
This peptide is currently being studied in conjunction with GH deficiencies and eating disorders to increase food intake and speed up human metabolism.
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