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IGF-1 LR3 Research Peptide
Peptides are short chains of amino acids that are made by the body. The building blocks of protein are called amino acids, and these amino acids are made to control certain functions in the human body.
As a form of therapy, peptides are used to take existing sequences and rewrite them so that they might be able to control and renew functions. To put it more simply, they attach to other cells and tell them what to do, imitating or replacing the functions of the natural peptide. Peptides may be able to change the way the body works to help with homeostasis, repair, and anabolism.
Insulin-like Growth Factor 1, or IGF-1 for short, is a protein that is made by the IGF1 gene. It is a hormone with a structure that is very similar to insulin. It is made up of 70 amino acids. Its main job is to stimulate growth in the body because it controls how cells divide and die.
Synthetic IGF-1 is an alternative to Human Growth Hormone, which is only made by the pituitary gland (HGH). The pituitary gland doesn’t work as well as it used to as you get older, but IGF-1 has the same effects as growth hormone even without the pituitary gland.
IGF-1 Long R3, also called IGF-1 LR3, is a type of IGF where the amino acids have been changed chemically. It is made up of 83 amino acid sequence, and Arg(R) stands in for Glu(E) at position three, which is why it is called R3. Because the changes stop the drug from binding to proteins in the body, its half-life lasts longer [R].
IGF-1 LR3 is more powerful than regular IGF-1 because it binds to IGF-binding proteins less strongly. Its main job is to make IGF work better in the body. IGF-1 LR3 peptide also stops glucose from getting into cells, which helps the body burn fat. The difference between the medium and the receptor in terms of purity is >85% and >95%, respectively.
In a recent study, mice with the GH receptor KO gene were used to show that giving IGF-1 stimulates the growth (width) of the tibial growth plate and that this effect is not caused by GH. These results are similar to what was found when IGF-1 was given to rats that had their testes removed. [R].
IGF-1 DES is a potent growth factor found and can be extracted from animals such as cows and pigs. It resembles a hormone produced by our bodies, but lacks the first three amino acids found in the original hormone. This makes it less likely to bind with certain proteins in the human body, allowing it to work more directly. However, this also means that it has a shorter half-life in the body and must be taken immediately after a workout to be most effective.
Using IGF-1 DES in this manner can help muscle repair and grow more quickly, but it is important not to overdose on nutrients.
IGF-1 has a similar structure to insulin and can bind to the insulin receptor, although with a lower affinity than the IGF-1 receptor. IGF-1 promotes anabolic effects in adults and is crucial for cell growth and differentiation during childhood. When the anterior pituitary gland produces GH, it stimulates the production of IGF-1, which binds to IGF-1 receptors on the surface of the majority of cells in the body. The IGF-1 receptor is composed of two alpha and two beta subunits that, when activated by the binding of IGF-1 to the alpha subunits, activate multiple signaling pathways that promote cellular survival and growth.
IGF1 LR3 and IGF1 DES function by binding to the IGF-1 receptor and activating the same signaling pathways as IGF-1. IGF1 LR3 has a longer half-life, allowing it to remain active in the body for a longer period of time, thereby promoting greater muscle growth and repair. IGF1 DES has a shorter half-life, but is more potent and has a faster onset of action, making it more effective for short-term muscle growth and recovery.
Multiple animal and cell-based studies have been conducted on IGF1 LR3 DES. This research chemical has also been the subject of clinical research. All these pieces of research have shown that IGF1 LR3 DES has therapeutic uses for diseases such as cancer, Parkinson’s disease, autoimmune diseases, muscle atrophy, and type 2 diabetes.
However, in the absence of randomized, large-scale, placebo-controlled trials, the FDA is yet to approve IGF1 LR3 DES for human consumption. Therefore, Behemoth Labz sells IGF1 LR3 DES for laboratory and research use only, not for human use.
A study was carried out in mouse models to investigate the potential for IGF-1 to protect muscle cells in the areas of the brain that become impaired as a result of Parkinson’s disease. According to the findings of the study, administering IGF-1 to rats prior to a treatment that reduces levels of dopamine can protect certain regions of the brain and activate signals that encourage the survival of cells. Based on these findings, it appears that IGF-1 may hold promise as a treatment option for Parkinson’s disease. [R]
In the context of cancer research, it explains that the IGF-IR pathway plays a crucial role in the development and progression of cancer, and it demonstrates that inhibiting this pathway has antitumor effects. In addition, the article discusses numerous methods for targeting IGF-IR, such as monoclonal antibodies, tyrosine kinase inhibitors, and small interfering RNA. It concludes that focusing on the IGF-IR pathway as a potential cancer therapeutic target is an exciting avenue to pursue. In addition, it is crucial to emphasize the significance of conducting additional studies to enhance the efficacy of this treatment for cancer patients. [R]
Recent research indicates that growth hormone (GH), the insulin-like growth factor (IGF) pathway, and the immune system interact. IGF-I levels decline with age and in chronic inflammatory diseases, resulting in weakened immune responses. However, children with chronic inflammatory diseases exhibit a developmental disorder, possibly as a result of IGF-I/GH dysfunction brought on by an overabundance of proinflammatory cytokines. Multiple immune cells, including hematopoietic cells, B and T lymphocytes, macrophages, and neutrophils, grow via the IGF pathway. IGF-I administration stimulates the maturation of B cells and influences the growth of thymic and splenocyte cells. Depending on their level of activation, T lymphocytes express IGF-I, IGF-II, IGF-IR, and IR differently. Activated macrophages and neutrophils exhibit an increase in IGF-I expression, which contributes to innate immune responses. These findings highlight the significance of the GH/IGF-I pathway in immune functions, despite the fact that the underlying mechanisms are not fully understood. [R]
Patients with chronic illnesses, burn injuries, spinal injuries, and those who travel to space often experience muscle weakness and muscle wasting. Nutritional supplements and exercise can help, but they may not be very effective. Some treatments use a hormone called insulin-like growth factor (IGF-1) to prevent muscle loss, but it can cause low blood sugar levels.
However, in this study, a modified version of IGF-1 was used that is attached to a protein (BP3) found in the body, which reduces the risk of low blood sugar. When given to rats with suspended hind limbs, this modified IGF-1 helped preserve muscle and body mass, and prevented muscle breakdown. The researchers suggest that this treatment may help prevent muscle loss in people with catabolic conditions, but more research is needed to confirm this.[R]
As we age, our bodies undergo numerous changes, including the loss of muscle mass and the accumulation of fat. This procedure was the focus of an investigation. The study included 21 healthy men between the ages of 61 and 81 who had low blood levels of the hormone IGF-I. They were observed without treatment for six months before receiving either human growth hormone or no treatment for another six months.[R]
Researchers discovered that men who received human growth hormone had an 8.8% increase in lean body mass, indicating that they gained muscle cells. This suggests that human growth hormone may assist older individuals in maintaining or gaining muscle mass. It is essential to note, however, that additional research is necessary to confirm these findings and determine whether this treatment is safe for older individuals.[R]
According to a previously mentioned study, the group also experienced a significant reduction in adipose-tissue mass of up to 14.4 percent. This decrease in plasma IGF-I concentrations is a normal aspect of the aging process in adults in good health. On the basis of these findings, it can be concluded that the decline in growth hormone secretion contributes to the loss of lean body mass and its constituent organs, as well as the common increase in adipose tissue in older adults. Interestingly, growth hormone administration led to a reduction in body fat and net energy consumption. [R]
Several studies were done to understand the relationship between IGF-I, insulin sensitivity, and type 2 diabetes. IGF-I is synthesized in the liver in response to growth hormone and is usually bound to a protein in circulation. Studies have shown that low IGF-I levels are associated with a higher risk of insulin resistance, metabolic syndrome, and type 2 diabetes, but a recent study found a U-shaped association between IGF-I levels and the risk of developing type 2 diabetes. This suggests that both low and high IGF-I levels may increase the risk of type 2 diabetes.[R]
Additional studies are needed to clarify this relationship and to determine the potential clinical implications of these findings. Further research should also investigate the potential mechanisms underlying the effects of IGF-I on decreased insulin sensitivity and glucose homeostasis, including the role of IGF-binding proteins and other regulatory factors.
IGF1 LR3 DES (Insulin-like Growth Factor-1 Long Arg3) is not FDA approved for human use in the United States. It is considered a research peptide and is only approved for research purposes. It is not intended for human consumption or use as a drug, and any use of it for performance-enhancing or other purposes is considered illegal and unethical.
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IGF1 LR3 DES is one of the most potent growth factor that resembles a hormone produced by our bodies and promotes cell proliferation, cell to cell communication, and anabolic effects in adults. It contains glutamic acid, which is important for protein synthesis and has potential therapeutic uses for diseases such as breast cancer, Parkinson’s disease, autoimmune diseases, and muscle atrophy. However, its safety and effectiveness for human consumption require further research. IGF1 LR3 DES has a shorter half-life, but is more potent and has a faster onset of action, making it more effective for short-term muscle growth and recovery.
The stimulation of IGF-1 receptor (IGF1R) may promote malignant transformation by promoting cell proliferation, inhibiting apoptosis, and inducing dedifferentiation. IGF-1, including its derivative IGF-1 LR3, is a highly potent stimulus for cellular proliferation and division. While its primary effects are believed to be on connective tissues like muscle and bone, it may also promote cell division in other tissues, such as kidneys, liver, skin, nerves, lungs, and blood tissues. It is important to note that the potential negative effects of IGF-1 and its derivatives on cellular proliferation and differentiation require further research and evaluation.
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Dale M. Shelton –
Periodically I run 100mcg a day for 4 weeks. As an additive, enhances my cycle. I would recommend. Does not have the fat reduction of HGH. Increases LH and FSH. I also noticed load increase.
B Thiele –
Every order processed fast, and all of it excellent quality! I recommend this to professional sportsmen.
Israel L –
Jeffrey G –
Dallin Nikolaus –
Excellent customer service. I will order again.
Phizell C –
It works slowly but is very effective. I have no complaints
Best deal I have found! Products are pure and true. Perfect for research.
Shawn Wright –
Supplying me with the best quality available.
Shawn Stewart –
This is fantastic for Crossfit training.
R. Deckow –
Juan C –
I just started taking this supplement, and I can already see the progress.
S K –
Finn Howe –
IGF1 LR3 DES seem to help, the shipment is quick and easy. I can only recommend behemoth.
I am very grateful for this supplement. My performance and gains really improved.