IGF-1 LR3 (Media Grade)

IGF-1 LR3 (Media Grade) (Peptide) – Product Details

• This peptide is offered as a 1mg powder

To facilitate research, it is advisable to mix this compound with Acetic Acid 0.6%. The inclusion of acetic acid in the IGF solution is crucial for preserving its activity by maintaining pH balance and stability. Additionally, acetic acid aids in achieving optimal dispersion and enhancing the solubility of the IGF compound, thereby preventing degradation.

What is IGF-1?

Insulin-like Growth Factor 1, or IGF-1 for short, is a protein encoded by the IGF1 gene. It contains 70 amino acids and is a hormone with a structure very similar to insulin. Due to its regulation of cell division and cell death, its primary function is to modulate cellular proliferation pathways within the research subject.

Synthetic IGF-1 is an alternative to the pituitary gland’s exclusive production of Growth Hormone. The function of the pituitary gland declines with age of the research model, but IGF-1 elicits comparable downstream signaling cascades to endogenous GH without the pituitary gland.

IGF-1 Long R3, or IGF-1 LR3, is a form of IGF in which the amino acids have been chemically altered. It consists of 83 amino acids, with Arg(R) serving as a substitute for Glu(E) at position three; hence, the name R3. The alterations prevent the compound from interacting with binding proteins in experimental biological systems, thereby extending its half-life.

IGF-1 LR3 is more potent than regular IGF-1 because Long R3 IGF-1 binds less strongly to IGF-binding proteins. Its primary function is to potentiate IGF-mediated signal transduction. Additionally, IGF-1 LR3 peptide modulates glucose transport across cellular membranes to upregulate fatty acid β-oxidation pathways. In terms of purity, the difference between the media and the receptor is >85% and >95%, respectively

IGF1 LR3 (Media Grade) – Product Information

 A recent study utilizing mice with the GH receptor KO gene showed that IGF-1 research exposure modulates growth-related signaling pathways of the tibial growth plate and that IGF-1 has a GH-independent effect on the growth plate. These findings are similar to those found when testing hypophysectomised rodent models with IGF-1

IGF-1 LR3 Research Peptide

• CAS Number is stated as 946870-92-4
• Molar Mass is 9117,60 g·mol−1
• It has a Chemical Formula of C400H625N111O115S9
• IUPAC Name: (insulin-like growth factor-1 long arginine 3
• Also known by Synonyms as IGF-I, IGF1A, IGFI

What is IGF1 LR3 (Media Grade)?

IGF-1 LR3, or Long R3 Insulin-Like Growth Factor-1, is a modified version of the naturally occurring insulin-like growth factor-1 (IGF-1). IGF-1 LR3 has a longer half-life and increased potency compared to native IGF-1. Insulin-like growth factor I (IGF-I) is critical in the morphogenesis and cellular expansion of various tissue types. IGF-I coordinates with other growth factors to facilitate satellite cell mitosis, initiate cellular lineage specification, and stimulate contractile protein fiber assembly in skeletal tissue during normal growth and remodeling following experimental trauma.

These actions can also induce myocellular enlargement, which supports biomechanical performance in contractile tissue. Consequently, IGF-I is a principal focus in experimental models investigating cellular kinetics for modulating contractile tissue activity associated with senescence and pathological states and advancing structural restoration in response to acute physiological insult.

IGF-1 is synthesized primarily in the liver and expressed locally in peripheral tissues under the control of pituitary growth hormone (GH). IGF-1 appears to modulate GH secretion via a negative feedback mechanism. The GH/IGF-1 signaling pathway is vital for supporting biosynthetic pathways involved in macronutrient assimilation and utilization in controlling organismal mass accumulation during the initial ontogenetic development period. Six binding proteins (IGFBPs) with separate biological functions influence the bioavailability and bioactivity of IGF-1.

How Does IGF1 LR3 (Media Grade) Work?

IGF-1 LR3 works by binding to the insulin receptor and the IGF-1 receptor on the surface of somatic cells, such as muscle cells. This binding initiates a cascade of intracellular signaling events that induce cellular mitosis and specialization. IGF-1 LR3 induces the mitotic expansion of satellite cells within myofascial tissue. Satellite cells are a subset of myogenic progenitor cells residing in muscle tissue. These satellite cells can differentiate into muscle fibers and integrate with pre-existing myofibrils, thereby promoting myofiber hypertrophy and tissue remodeling.

IGF-1 LR3 also upregulates polypeptide biosynthesis in muscle cells, facilitating myofiber hypertrophy and increased muscle force generation. Furthermore, it modulates muscle atrophy by suppressing the activation of catabolic proteases involved in muscle protein degradation.

Where to Buy IGF1 LR3 (Media Grade) for Sale?

BehemothLabz is the best place to buy IGF1 LR3 (Media Grade) online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free shipping, and a money-back guarantee. We carry IGF1 LR3 (Media Grade) liquid, parenteral solution IGF1 LR3 (Media Grade), and IGF1 LR3 (Media Grade) capsules.

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