Leptin 22-56

Leptin 22-56 (Peptide) – Product Details

Leptin is a hormone involved in the regulation of energy balance and appetite. The specific sequence “22-56” refers to a fragment or segment of the leptin peptide, often used in research contexts.

• CAS Number: 177404-21-6
• Molar Mass: 2004.3 g·mol⁻¹
• Chemical Formula: C₈₇H₁₃₈N₂₂O₂₈S₂
• IUPAC Name: VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQ

What is Leptin 22-56?

Leptin (22–56) is a biologically active peptide fragment derived from the full-length leptin hormone. This fragment has been investigated in non-human research models for its potential role in modulating physiological processes related to energy balance, metabolic signaling, and cellular communication through leptin receptor pathways.

Leptin itself is a peptide hormone composed of 146 amino acids, primarily synthesized in white adipose tissue. The leptin gene is located on chromosome 7q31.3. It shares structural similarities with certain proinflammatory cytokines, such as interleukin-6. Leptin levels in the bloodstream have been shown in animal models to correlate directly with adipose tissue mass, suggesting its involvement in energy storage feedback loops.

The leptin receptor (LR), a member of the gp130 cytokine receptor family, plays a central role in mediating the biological effects of leptin via activation of the JAK-STAT signaling pathway. LR isoforms have been identified in multiple tissues, including neuronal, hepatic, pancreatic, cardiac, and gastrointestinal systems.

How Does Leptin 22-56 Work?

In preclinical and animal-based studies, Leptin (22–56) has been explored for its interaction with various isoforms of the leptin receptor (Ob-R). These receptors, particularly the long isoform (Ob-Rb), have been shown to activate intracellular pathways such as JAK2-STAT3, which may influence downstream signaling events related to energy metabolism, appetite modulation, and inflammatory responses.

In non-human models, leptin primarily exerts its regulatory effects in the central nervous system, particularly within the hypothalamus and brainstem. Research in rodents has demonstrated that leptin interacts with hypothalamic nuclei such as the arcuate nucleus (ARC) to influence appetite-related signaling. Specifically, it appears to stimulate POMC-expressing neurons and inhibit AgRP/NPY-expressing neurons, which may contribute to reduced food intake and enhanced energy expenditure.

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