Ligandrol is a novel nonsteroidal oral selective androgen receptor modulator currently being investigated in research as a potential treatment for conditions relating to muscle dystrophy and osteoporosis.
What are SARMs?
SARMs, or selective androgen receptor modulators, are compounds that may have the potential to help build muscle mass and reduce body fat. They are being researched for the potential to produce similar effects to anabolic compounds but have reduced androgenic properties, which means their side effects will be less intense.
SARMs were originally developed to treat and manage musculoskeletal diseases such as muscle wasting and osteoporosis. Once it became known that they consist of the potential to build lean muscle mass and shred body fat, SARMs became the favorite subject of researchers and scientists.
How Does Ligandrol Work?
Ligandrol LGD-4033 works by binding androgen receptors (ARs) on a tissue-selective basis. It primarily targets ARs in the bone and muscle tissues, sparing the vital organs. This distinguishes LGD 4033 and other SARMs from testosterone and conventional anabolic compounds, whose approach isn’t as targeted.
What are the Potential Benefits of LGD-4033
LGD-4033 and Potential on Muscle Mass and Strength
In the phase 1 clinical trial, 76 healthy men (ages 21-50 years) were randomized to placebo or 0.1, 0.3, or 1.0mg LGD-4033 daily for 21 days. Among other metrics, lean and fat mass and muscle strength were measured during and for 5 weeks after intervention.
LGD 4033 increased lean body mass in a dose-dependent manner. The gains in lean body mass were similar to those reported with Ostarine, although the treatment duration in the Ostarine trial was substantially longer (12 weeks). [R] [R]
The phase 1 clinical trial also noted the effect of LGD-4033 on muscle strength. An increase in muscle strength averaging 68.3N was observed among the 1.0mg dose group, but this change was not significantly different from that in the placebo group.
LGD-4033 and Potential Effects on Bone
A preclinical study on LGD-4033 observed that Ligandrol increased bone density and bending strength (an indicator of resistance to fracture) in osteopenic female rats. [R]
Statistically significant improvements in bone mineral density were also observed after 12 weeks of administering LGD-4033 at doses as low as 0.03mg/kg/day (in cortical bone) and 0.3mg/kg/day (in cancellous bone).
Where to Buy LGD-4033
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LGD 4033 Ligandrol Capsules
CAS Number is stated as 1165910-22-4
Molar Mass is 338.253 g·mol−1
It has a Chemical Formula as C14H12F6N2O
IUPAC Name is 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Also known by Synonyms as VK5211; LGD-4033.
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