Lipopeptide (Peptide) – Product Details

Lipopeptide is a research chemical consisting of amino acids and a fatty acid molecule that connects to and transports peptides across cell membranes, unlike water-soluble peptides. When added to mammalian tissue culture cells, this cyclic lipopeptide may stimulate toll-like receptors to potentially trigger collagen production and new collagen synthesis.

By mimicking hyaluronic acid in the skin’s natural structure, Lipopeptide may boost collagen production and the skin’s maximum growth potential. However, Lipopeptide is intended for laboratory and research use only, not for human consumption.

Researchers should conduct their review regarding Lipopeptide’s potential to stimulate collagen synthesis in existing skin and other tissues. While early scientific studies show promise for research applications related to antifungal and antibacterial agents, additional research is needed to fully understand Lipopeptide’s natural function and benefits.

Customers should use appropriate safety precautions when handling this research chemical, as effects may differ between laboratory and real-world conditions. Lipopeptide is not intended to diagnose, treat, cure, or prevent any disease or health condition.

What is Lipopeptide?

A lipopeptide is a molecule consisting of a lipid connected to the peptide. Unlike water-soluble peptides, the fatty acid chain allows lipopeptides to insert into cell membranes. Lipopeptide antibiotics work by altering bacterial cell membranes and are used in parasitology research. There are natural lipopeptides like cyclic lipopeptides that act on toll-like receptors as part of the skin’s natural structure and function.

Synthetic lipopeptide may also stimulate existing skin cells, with some scientific studies showing a possible increase in collagen synthesis in mammalian tissue culture cells. However, more research is needed on actual human subjects, as lipopeptides potentially enable maximum growth potential for new collagen production. Currently, lipopeptides are best limited to laboratory and research use, including as research chemicals for antifungal and antibacterial agents.

• CAS Number: 103060-53-3
• Molar Mass: 994.3 g·mol−1
• Chemical Formula: C50H87N7O13
• IUPAC Name: 3-[(3S,6S,9S,12S,15S,18S,21S)-9-(carboxymethyl)-25-(7-methyl octyl)-3,6,15,18-tetrakis(2-methyl propyl)-2,5,8,11,14,17,20,23-octaoxo-12-propan-2-yl-1-oxa-4,7,10,13,16,19,22-heptazacyclopentacos-21-yl]propanoic acid

Potential Applications of Lipopeptide

Anti-Aging Skin Research

It also describes pharmaceutical uses like antimicrobials, vaccines, immunotherapy, and cancer medications. In both industries, the unique structures and self-assembly tendencies enable lipopeptides to serve diverse functional roles.

Lipopeptides may enhance the skin’s structural proteins like collagen. Increased collagen helps make skin more supple and resilient. This may decrease visible wrinkling and give a younger-looking complexion as we age. Lipopeptides may also have the potential to reinforce the skin’s protective barrier against environmental harm. [R]

Healthy barrier function provides potential natural defense versus pollution and irritants by controlling what penetrates the skin’s outermost layer. Overall, lipopeptides show promise to nurture collagen-based firmness and barrier shielding that underlie smooth, youthfully intact skin. [R]

More research should further define optimal formulations and regimens for tangible anti-aging skin benefits. [R]

Antimicrobial and Antifungal Potential Effects

Lipopeptides produced by Bacillus bacteria have been tested as versatile tools to potentially combat various plant pathogens. The three main families of Bacillus lipopeptides – Surfactins, Iturins, and Fengycins – have been studied for their ability to inhibit a wide range of plant pathogens including bacteria, fungi, and oomycetes. [R]

Iturins and Fengycins have antifungal effects, while Surfactins have broad and potent antibacterial activities and have also been used as insecticides. Importantly, these biologically derived lipopeptides are environmentally friendly. [R]

Lipopeptides have broader potential applications in plant disease management, cosmetics, and food preservation, as well as surfactants, antiparasitic, antiviral, and antitumor/cancer agents.

These lipopeptides appear to be promising biopesticides in agricultural practices for replacing harmful chemical pesticides, and they may thus be regarded as potent alternative tools for combating the increasing chemical resistance of phytopathogens. Lipopeptides are biomolecules that are potentially nontoxic, biodegradable, highly stable, environmentally friendly, and nonpolluting. [R]

These lipopeptide properties make them more efficient biologics for use in phytosanitation, pharmaceuticals, foods, bioremediation, and other applications. Iturin and Fengycin are potential novel environmentally friendly solutions for combating resistant phytopathogen races in agricultural practices. [R]

Research on Anti-inflammatory Activity

Scientists have tested synthetic lipopeptides in lab dishes with human cells and found they may reduce inflammation. Researchers published results on some newly created lipopeptide molecules that were able to block Toll-like receptor signaling. Toll-like receptors are proteins on cells that play major roles in inflammation when they are activated. [R]

By interfering with these Toll-like receptor signals using lipopeptides, inflammation was decreased. This process could be beneficial in inflammatory skin diseases like psoriasis or eczema. The lipopeptides might also help calm down overactive immune responses in conditions like asthma, arthritis, or inflammatory bowel disease. [R]

More research is still required, but these early findings suggest artificial lipopeptides might someday make useful treatments for human inflammatory illnesses.[R]

Anti-Tumor Research

Surfactin is a lipopeptide that may act as an antitumor agent. Studies have shown surfactin may inhibit the growth and proliferation of different human cancer cell lines, including colon, breast, and blood cancer cells. It does this by interfering with pathways inside cancer cells that normally promote survival and prevent cell death. [R]

Specifically, surfactin generates reactive oxygen molecules that activate proteins like JNK and ERK, turning on apoptotic pathways leading to cancer cell death. The effects seem to depend on the dose of surfactin as well as how long cells are exposed. Overall, researchers think surfactin stops tumor progression by both slowing cancer cell proliferation and inducing programmed cell death. [R]

More work is still needed, but these cytotoxic effects make surfactin a promising natural compound for developing new cancer therapies.[R]

Lipopeptides produced by the bacteria Bacillus subtilis have shown potential anti-cancer effects in lab studies. Specifically, B. subtilis lipopeptides were able to possibly inhibit the growth and multiplication of human breast cancer cells growing in cultures and tumor models by disrupting Akt cell survival signaling. They may also trigger cell suicide (apoptosis) in human melanoma and leukemia cells by interacting with the cancer cell membranes. [R]

These bioactive B. subtilis lipopeptides have a fatty acid chain bonded to a circular peptide structure. This gives them anti-bacterial, anti-inflammatory, anti-viral, and anti-tumor properties. Some have been researched for use as antiviral agents or anti-cancer drugs. Three main examples – surfactin, iturin, and fengycin – have been studied extensively due to their anti-tumor effects in lab tests. [R]

How Does Lipopeptide Work?

Lipopeptides like the cyclic lipopeptide surfactin are bacterial metabolites that act as powerful antibacterial agents against a broad range of microbes. Their mechanism involves attaching a linear hydrophobic fatty acid chain to a hydrophilic peptide chain composed of amino acids connected by peptide bonds. This creates a molecule with a water-soluble peptide head connected to a lipid portion. Unlike water-soluble peptides alone, this dual structure enables lipopeptides to interact with cell membranes and enveloped viruses, disrupting their structure. [R]

Researchers have explored using the antibacterial properties of lipopeptide surfactin and other microbial surfactants as food additives for food safety and animal cell lines for parasitology research. Their biocompatibility also enables therapeutic applications against cancer, tumors, parasitic infections, and as antitumor agents.

Further research into optimizing culture conditions and bioactivity could boost yields and productivity levels for commercial and research purposes. 

In skin care, lipopeptides like surfactin have the potential to signal through toll-like receptors to stimulate collagen and hyaluronic acid synthesis in existing skin cells. By structurally supporting the skin’s natural extracellular matrix, lipopeptides offer quality products intended to be powerful anti-agers, reducing wrinkles and protecting skin.

Further studies on lipopeptide mechanisms of action and biological activity could reveal more potential applications in environmental protection, plant protection, and immunology.

Safety and Side Effects

As research-stage compounds, the safety profile of most lipopeptides has not been fully characterized for human consumption or topical use. Preliminary cytotoxicity studies indicate high biocompatibility and low toxicity at typical working concentrations used in cosmetics or therapeutics. However, some synthetic lipopeptides have shown inhibition of cytochrome enzymes in hepatocytes in vitro, indicating a potential for drug interactions or liver toxicity at high doses.

Further clinical safety and pharmacokinetic studies in humans will be essential if lipopeptides are to be translated from the laboratory into commercial products. Formulations and dosages may need careful optimization to balance efficacy with minimal side effects.

Frequently Asked Questions

What are lipopeptides?

Lipopeptides are molecules consisting of a lipid connected to a peptide. The lipid component provides hydrophobicity, allowing the molecules to interact with lipid-containing cell membranes, while the peptide component can engage in specific biomolecular interactions.

Where are lipopeptides found naturally?

Many lipopeptides are produced by bacterial and fungal species. For example, surfactin and iturin are cyclic lipopeptides made by Bacillus subtilis with surfactant properties. Some lipopeptides play signaling roles; others have antimicrobial or cytotoxic activities.

How are lipopeptides being used scientifically?

Researchers are studying lipopeptides for a wide range of potential therapeutic, agricultural, cosmetic, and other applications. Synthetic lipopeptides are being developed to modulate immune responses, transport drugs within the body, and stimulate collagen production in the skin. Naturally-derived lipopeptides are being explored as antifungal treatments in plants.

Why Buy Lipopeptide from BehemothLabz?

BehemothLabz is the best place to purchase Lipopeptide online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee on Lipopeptide.

Summary

Lipopeptides are molecules consisting of a lipid connected to peptides of various structures like short chains or cyclic lipopeptides. Unlike water-soluble peptides, the fatty acid chain of lipopeptides allows insertion into cell membranes and enveloped viruses, disrupting causative agents. This gives lipopeptides broad biological activity as antibacterial agents even under culture conditions less suitable for host apis mellifera – the smallest free-living organisms. 

Research shows lipopeptides have significant potential benefits: potentially stimulating new collagen production and hyaluronic acid to improve skin’s natural structure; reducing parasitic infection for plant protection; altering microbial surfactants as research chemicals or lipopeptide antibiotics; and antitumor agents against animal cell lines.

Cyclic lipopeptides like surfactin demonstrate high productivity levels and good pricing for customers interested in powerful anti-agers.

More research applications are needed before widespread human consumption. However, quality evidence continues emerging on the ability of these lipid-attached peptides to enable maximum growth potential of existing skin cells through toll-like receptors that synthesize collagen and peptide bonds.

For now, lipopeptides present prime candidates for customers intending research purposes or laboratory use instead of personal review. Their highly biocompatible lipid and peptide components provide researchers with many options to develop products offering environmental protection, food safety additions, and therapeutic applications.

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Strength	50mg