The Bulker Capsules (RAD-140 + YK-11 + MK-2866 + ACP-105)

The Bulker Capsules combine several potent research compounds, each selected for its unique potential. Featuring RAD-140, YK-11, MK-2866, and ACP-105, these capsules offer a multifaceted approach to potentially enhancing physical performance. However, understanding the long-term safety and effectiveness of these compounds, especially when used together, is crucial.

Would you like to keep track of the specific SARMs and their potential benefits for future reference? Read on. 

The Bulker Capsules (RAD-140 + YK-11 + MK-2866 + ACP-105) Product Description 

RAD-140

• CAS Number is stated as 1182367-47-0
• Molar Mass is 393.83 g·mol−1
• It has a Chemical Formula of C20H16ClN5O2
• IUPAC Name is 2-chloro-4-{[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methyl benzonitrile
• Also known by Synonyms as Testolone; vosilasarm; EP 0062; EP-0062; EP0062 [R]

YK-11 Myostine

• CAS Number is stated as 1370003-76-1
• Molar Mass is 430.541 g·mol−1
• It has a Chemical Formula of C25H34O6
• IUPAC Name is Methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate
• Also known by Synonyms as YK11; (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester.

MK-2866

• CAS Number is stated as 841205-47-8
• Molar Mass is 389.334 g·mol−1
• It has a Chemical Formula of C19H14F3N3O3
• IUPAC Name is ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide)
• Also known by Synonyms as GTx-024; MK-2866; Ostarine; S-22

ACP-105

• CAS Number: 1048998-11-3
• Molar Mass: 290.79 g·mol−1
• Chemical Formula: C16H19ClN2O
• IUPAC Name: 2-chloro-4-(3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl)-3-methylbenzonitrile
• Also known by Synonyms as Benzonitrile,2-chloro-4-(3-hydroxy-3-methyl-8-azabicyclooct-8-yl)-3-methyl-; 2-Chloro-4-(3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile; AC 264184

What are The Bulker Capsules (RAD-140 + YK-11 + MK-2866 + ACP-105)? 

The Bulker Capsules are a combination of high-quality research compounds. Each capsule contains the following ingredients:

• RAD-140 10mg
• YK-11 10mg
• MK-2866 20mg
• ACP-105 15mg
• The Bulker is offered as 55 mg per capsule for 60 capsules, totaling 15.6g.

What is RAD-140?

A selective androgen receptor modulator (SARM) known as RAD-140, commonly referred to as Testolone, is made to specifically bind to androgen receptors in the body, which can encourage the growth of lean muscle mass and bone density without the negative side effects associated with anabolic steroids. It has been demonstrated that RAD-140 has a high affinity and selectivity for the androgen receptor. [R] 

This research compound is now being studied for its possible therapeutic applications in diseases such as muscular atrophy, osteoporosis, and breast cancer. [R]

BehemothLabz sells RAD-140 for laboratory research use only.

We also carry RAD-140 Testolone Capsules and RAD-140 Testolone Liquid if you’re looking for those instead.

What is YK-11? 

YK 11 is a myostatin inhibitor and a type of selective androgen receptor modulator. Studies have revealed that YK 11 has a chemical structure similar to dihydrotestosterone (DHT), a more powerful version of testosterone that has the potential to act on androgen receptors in the liver, hair, sex organs, and prostate.

Compared to other SARMs that act as full agonists of the androgen receptor, YK 11 may only partially activate this receptor. Moreover, it differs from popular SARMs in that it inhibits myostatin production. Most SARMs do not seem to have any impact on myostatin production. [R]

BehemothLabz sells YK-11 for laboratory research use only.

We also carry YK-11 Liquid and YK-11 Capsules if you’re looking for those instead.

What is MK-2866? 

Ostarine MK 2866 is a type of selective androgen receptor modulator (SARM) that targets androgen receptors in a specific manner. Unlike anabolic compounds or testosterone, it is being primarily researched for its applications on muscle and bone tissue while leaving reproductive organs relatively unaffected.

This selectivity of Ostarine has the potential to reduce the risk of severe side effects, allowing researchers to study this SARM in female and elderly participants. Nonetheless, prolonged and randomized human trials are essential to confirm its safety.

BehemothLabz sells  MK-2866 for laboratory research use only.

We also carry MK-2866 Liquid and MK-2866 Capsules if you’re looking for those instead.

What is ACP-105? 

ACP-105, a selective androgen receptor modulator (SARM), is being researched for its potential to treat a number of illnesses associated with muscle wasting, including sarcopenia and cachexia. Similar to other SARMs, ACP-105 selectively binds to androgen receptors in skeletal muscle tissue. [R]

BehemothLabz sells ACP-105 for laboratory research use only.

Potential Applications of The Bulker Capsules (RAD-140 + YK-11 + MK-2866 + ACP-105)

RAD-140 and Breast Cancer

Exploring the capabilities of RAD140 in potentially addressing breast cancer, particularly AR/ER+ variants, presents a compelling avenue of investigation. This specific breast cancer subtype is identified by the presence of both androgen and estrogen receptors, which contribute to tumor development through hormonal channels. [R]

Experimental research has demonstrated that RAD140, a Selective Androgen Receptor Modulator (SARM), effectively inhibits the proliferation of AR/ER+ breast cancer cells. It obstructs estrogen’s influence, particularly targeting the ESR1 gene responsible for estrogen receptor production. By decreasing these receptors, RAD140 potentially reduces estrogen’s capacity to promote tumor growth. [R]

The results of these experiments indicate that RAD140 SARMs might be an effective treatment for AR/ER+ breast cancer. By interfering with the hormonal processes that contribute to tumor growth, RAD140 might help slow down or stop the progression of this aggressive cancer type. [R]

Despite these encouraging findings, additional research is necessary to thoroughly understand RAD140’s potential in practical medical scenarios. Clinical trials are vital to confirm the safety and efficacy of RAD140 in test subjects with AR/ER+ breast cancer. 

RAD-140 and Muscle Building

RAD140 has garnered significant attention for its potential to boost muscle growth, but the scientific backing for this claim is relatively sparse. To date, only a single animal study has investigated RAD140’s effects on muscle development. [R]

In this study, researchers administered various doses of RAD140 to a group of nine monkeys. The monkeys that received daily doses of RAD140 exhibited a potential increase in lean muscle mass after 28 days. However, it is essential to recognize that this study had a small sample size and was conducted on a different species, which may limit the direct applicability of the findings to human test subjects. [R]

It is vital to comprehend that RAD140 is a Selective Androgen Receptor Modulator (SARM), distinct from traditional steroids. SARMs are designed to selectively target androgen receptors in muscle and bone tissue, potentially promoting muscle growth without the adverse effects often associated with steroids. Nevertheless, the long-term safety and efficacy of RAD140 in human test subjects have not been extensively studied. [R]

YK-11 and Muscle Size

YK11 has demonstrated promising potential in enhancing muscle size based on cellular studies. By increasing follistatin levels and inhibiting myostatin, YK11 is believed to promote muscle growth. This dual mechanism of action is thought to contribute to the augmentation of muscle size and development. It is crucial to acknowledge that these conclusions are predominantly drawn from cellular research, highlighting the need for additional studies, particularly involving animal and human subjects, to comprehensively assess and confirm YK11’s ability to enhance muscle size in real-world scenarios. [R]

YK-11 and Bone Strength

The bone strength potential of YK-11 is an area of ongoing research. As a Selective Androgen Receptor Modulator (SARM), YK-11 binds to androgen receptors in bone tissues, mimicking the effects of steroids and other SARMs. This binding action may contribute to increased bone strength by stimulating bone growth and development. [R]

Studies have demonstrated that YK-11 may elevate activated protein kinase B (PKB) levels within cells. This activation of PKB sends signals that potentially promote bone growth, suggesting a possible mechanism by which YK-11 might fortify bones. This mechanism is similar to that of other SARMs, which are also being investigated for their potential benefits in promoting bone health. [R]

The potential benefits of YK-11 in enhancing bone health are particularly significant for older test subjects who often experience muscle and bone frailty. However, it is essential to note that the current evidence is primarily based on cellular studies and lacks definitive proof from human test subjects or animal trials. Further research is necessary to validate the efficacy and safety of YK-11 in potentially enhancing bone health and to determine its optimal dosage and application regimens.

MK-2866 Ostarine and Diabetes

Ostarine, a Selective Androgen Receptor Modulator (SARM), has shown potential in addressing diabetes and metabolic syndrome. The primary compound in Ostarine, Enobosarm, has been found to improve insulin sensitivity and lower blood sugar levels in initial studies and clinical trials.

In one clinical trial involving 120 elderly male and female test subjects, Ostarine treatment potentially led to an increase in lean body mass and enhanced physical function. Another study with 60 elderly male test subjects  and 60 postmenopausal female test subjects indicated that those receiving Ostarine had reduced insulin and glucose levels and improved insulin resistance compared to baseline. These improvements were especially notable in prediabetic participants. [R]

Changes in body composition, such as increased muscle and decreased fat, resulting from Ostarine treatment appear to positively impact insulin resistance. These findings suggest that Ostarine might benefit prediabetic conditions and possibly diabetes, with potential expanded indications if further studies confirm these results. [R]

Additionally, research on isolated rat fat cells showed that Ostarine influences carbohydrate-lipid metabolism, enhances fat breakdown, and inhibits fat formation. This supports the potential role of Ostarine in managing metabolic disorders. [R]

While these outcomes are promising, more research is needed to fully understand the safety and effectiveness of Ostarine in potentially treating diabetes and metabolic syndrome. Larger clinical trials with diverse patient groups are essential to confirm these findings and determine proper dosing regimens.

MK-2866 Ostarine and Muscle Mass

Ostarine, also known as MK-2866, has shown promise in preventing muscle loss in diverse groups such as cancer test subjects, participants with muscular dystrophy, and older test subjects. As a Selective Androgen Receptor Modulator (SARM), Ostarine has demonstrated encouraging results in clinical trials, highlighting its potential ability to build muscle and its favorable safety profile. [R]

In a study involving 120 healthy elderly test subjects, daily use of Ostarine over 12 weeks resulted in a potentially significant increase in lean body mass and improved physical function.  [R]

Additionally, research on isolated rat fat cells showed that Ostarine  potentially influences carbohydrate-lipid metabolism, possibly enhances fat breakdown, and inhibits fat formation. This supports the potential role of Ostarine in managing metabolic disorders.

ACP-105 and Osteoporosis

ACP-105 has emerged as a promising option for potentially treating degenerative bone conditions like arthritis and osteoporosis. Developed as a safer alternative to traditional anabolic steroids and prohormones, ACP-105 aims to deliver benefits while minimizing associated risks. [R]

ACP-105 functions by binding to androgen receptors found in both bone tissue and muscles. Its potent anabolic effects are comparable to testosterone but with a selective nature that enhances safety. In laboratory tests, ACP-105 has demonstrated efficacy similar to testosterone without affecting other hormone receptors. [R]

In a study, researchers explored the effects of ACP-105 on female mice models exposed to either sham irradiation or irradiation with 137 Cesium, a model for radiation-induced bone loss. The results indicated potential benefits of ACP-105 for bone health in this context. [R]

Furthermore, ACP-105 shows potential in providing therapeutic benefits while potentially enhancing safety profiles for test subjects. By offering a safer approach to improving lean muscle mass, strength, and endurance without the severe side effects linked to traditional steroids, ACP-105 emerges as an appealing option for addressing degenerative bone disorders.

Nevertheless, it’s essential to acknowledge that current evidence primarily stems from laboratory and animal studies. Further exploration, especially through human clinical trials, is essential to thoroughly assess the effectiveness and safety of ACP-105 in managing osteoporosis and other degenerative bone conditions.

How Do The Bulker Capsules (RAD-140 + YK-11 + MK-2866 + ACP-105) Work? 

The Bulker Capsules blend several SARMs (Selective Androgen Receptor Modulators) known for their potential muscle-building and bone-strengthening effects. RAD-140 (Testolone) shows early promise in halting certain breast cancer types by blocking estrogen effects, though further clinical validation is needed. 

YK-11 shows promise in potentially enhancing muscle growth by increasing follistatin levels, but further research in animals and humans is needed for validation. MK-2866 (Ostarine) has shown in clinical trials its potential to manage blood glucose and prevent muscle loss in diverse populations, including older adult test subjects and cancer test subjects. ACP-105, recognized for its potential in bone health through binding to androgen receptors in bone and muscle tissues, requires human trials to establish its effectiveness and safety in potentially treating osteoporosis and similar bone conditions. 

While these SARMs hold promise, current evidence is largely from early studies and animal research, necessitating comprehensive human trials to assess long-term safety and effectiveness, especially when combined. 

Safety and Side Effects

The safety and potential adverse effects linked to The Bulker Capsules, which contain a blend of SARMs such as RAD-140, YK-11, MK-2866 (Ostarine), and ACP-105, warrant attention. While SARMs are intended to target specific tissues like muscle and bone, they carry inherent risks. Commonly reported side effects include testosterone suppression, lipid imbalances, and potential liver toxicity. Moreover, the long-term consequences and interactions of these compounds, especially when used together, are not fully understood. 

Frequently Asked Questions

What are the primary mechanisms of action of The Bulker Capsules? 

RAD-140 is thought to inhibit the progression of specific breast cancer types by interfering with estrogen’s actions. YK-11 potentially supports muscle development by increasing follistatin levels, which suppresses myostatin. MK-2866 (Ostarine) helps regulate blood glucose and enhances insulin sensitivity, potentially aiding in the management of diabetes and metabolic syndrome. ACP-105 interacts with androgen receptors in bone and muscle tissue, encouraging osteoblast differentiation and bone mineralization.

What are the potential side effects associated with RAD-140, YK-11, MK-2866, and ACP-105?

Reported side effects often include testosterone suppression, lipid imbalances, and possible liver toxicity. Clinical trials have also noted cases of mild liver cell injuries and elevated ALT levels. Additionally, there have been associations with rhabdomyolysis and myocarditis, although a definitive causal link has not been established in all instances.

How do RAD-140, YK-11, MK-2866, and ACP-105 compare in terms of their efficacy and safety profiles?

RAD-140 has demonstrated potential in inhibiting the growth of certain breast cancer types, while YK-11 has been shown to enhance muscle growth and promote osteoblast differentiation. MK-2866 (Ostarine) has proven beneficial in managing diabetes and metabolic syndrome. ACP-105 also supports osteoblast differentiation and bone mineralization. 

Are RAD-140, YK-11, MK-2866, and ACP-105 approved for medical use?

None of these compounds are currently approved for medical use. They are primarily used as research tools and are not yet widely available for therapeutic purposes. Further studies are needed to fully understand their efficacy and safety profiles before they can be recommended for clinical use.

Summary

The Bulker Capsules combine RAD-140, YK-11, MK-2866, and ACP-105, each potentially enhancing muscle growth and bone strength. RAD-140 might inhibit certain breast cancers, YK-11 could boost muscle development, MK-2866 may aid in diabetes management, and ACP-105 appears to potentially support bone health. However, the long-term safety and effectiveness of these compounds, especially when used together, are not fully known. It is crucial to consult healthcare professionals for personalized advice and monitoring. These products are for research purposes only and are not approved for human or veterinary use.

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Form	Capsules
Variant	55mg/60ct/15.6g

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