YK 11 (Myostine) is aSARM and a myostatin inhibitor. In animal studies, YK 11 has shown the potential for increased muscle mass, reversed muscle wasting, and decreased weight loss. YK11 has also been shown to repress the levels of pro-inflammatory cytokines in the bloodstream potentially.
Preliminary cell-based studies suggest that YK 11 may potentially enhance bone growth by increasing activated PKB (protein kinase B) levels in cells. PKB has been proven to send signals to increase bone growth.
Although YK 11 could be safer than anabolic steroids, this SARM is inadvisable for human consumption. Behemoth Labz sells YK 11 for laboratory research use only.
CAS Number is stated as 1370003-76-1
Molar Mass is 430.541 g·mol−1
It has a Chemical Formula of C25H34O6
IUPAC Name is Methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate
Also known by Synonyms as YK11; (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester.
What is YK 11?
YK 11 is a selective androgen receptor modulator and a myostatin inhibitor. Research has shown that YK 11’s chemical structure is similar to dihydrotestosterone (DHT). DHT is a more potent version of testosterone that acts on androgen receptors in the prostate, sex organs, hair, and liver.
Unlike most SARMs, which are full agonists of the androgen receptor (AR), YK 11 potentially only partially activates the androgen receptor. Another difference between YK 11 and popular SARMs is that it inhibits myostatin.
Most SARMs appear to potentially not affect whatsoever on the body’s myostatin production. [R]
Possible Uses of YK 11
YK11 is yet to attract any clinical or human studies. All the evidence about this research chemical’s potential treatment comes from cell-based or animal studies, which have shown that YK11 may have the potential to increase lean muscle mass, reverse muscle atrophy caused by sepsis, and strengthen bones.
Because of its incomplete profile and unknown side effects, YK 11 isn’t approved for human consumption by the FDA. All the information presented below is for educational purposes only. Behemoth Labz sells YK 11 for laboratory and research purposes only.
YK 11 and Muscle Growth
A cell-based study has shown that YK 11 may potentially increase muscle mass by inhibiting myostatin and thus enhancing (FST) follistatin levels. It was also noted that the anti-FST antibodies reversed YK 11’s strong anabolic effects.
This shows that the activation of FST is critical to YK 11’s potential anabolic activity. [R]
Another important observation the study made is that YK 11 might potentially be more potent in inducing myogenic differentiation and, in turn, muscle tissue growth than DHT.
This might prove to be a potentially crucial finding, given that DHT is one of the more potent muscle-building hormones in the body. [R]
The study’s results further clarify that YK 11 potentially takes a different route to induce anabolic factors than other SARMs and DHT. Most selective androgen receptors activate the AR to increase muscle growth, whereas YK 11 may depend on the activation of FST for the same.
YK 11 and Bone Health
In a cell-based study, YK 11 activated PKB (protein kinase B) in the osteoblast cells of mice. PKB are enzymes that, upon activation, send signals to stimulate bone growth.
PKB activation is a key regulator of androgen-mediated mediation of osteoblasts (cells that form bone tissue). [R]
Results from the study show that YK 11 increased the activity of osteoprotegerin, a protein that improves bone density and prevents osteoporosis during pregnancy. YK 11 also increased the activity of osteocalcin, a hormone that locks protein inside the bones to increase bone strength and density. [R][R]
YK 11 also accelerated osteoblast cell proliferation, the first step of bone formation. In addition, YK 11 promoted alkaline phosphatase (ALP) activity, a marker of bone maturation.
Thus, this cell-based study showed that YK 11 might potentially help in bones’ formation, strengthening, and maturation. [R]
YK 11 and Sepsis
An animal study found that myostatin inhibition by YK 11 treatment might decrease the mortality rate in septic mice. The study further showed that YK 11 might help revert muscle wasting during sepsis and subdue the inflammatory environment surrounding the disease. [R]
Results from this study show that YK 11 decreased weight loss in the mice in a concentration-dependent manner. That means that the total body weight of the septic mice increased or recovered better with increasing concentration of this myostatin inhibitor.
All in all, when administered to septic mice, YK 11 increased total body weight and reverted muscle mass loss and muscle cell atrophy.
Results from the study highlight the potential of YK 11 as a preventative agent for sepsis-related muscle wasting.
YK 11 and Body Fat
In the above study involving septic mice, YK 11 treatment caused fat loss. This result is consistent with previous studies showing a direct relationship between myostatin levels and fat loss.
One animal study has shown that mice lacking the myostatin gene have a widespread increase in skeletal muscle. Aside from that, myostatin-deficient mice experience a significant reduction in fat accumulation with increasing age compared with their wild-type counterparts. [R]
These effects aren’t limited to animals. A clinical study has detected a potentially significant reduction of myostatin in obese men after weight loss.
Potential changes in myostatin and fat-free mass by weight loss correlated positively in this small-scale human trial. [R]
How Does YK 11 Work?
YK 11 has the potential to attach to the androgen receptor (AR) to inhibit myostatin production in the muscle and bone tissue, hence its classification as a myostatin inhibitor. Myostatin is a protein that helps with the movement of skeletal muscles. Myostatin also limits muscle growth. [R][R]
Preliminary studies have shown that YK 11’s ability to inhibit myostatin production may potentially help stimulate muscle growth. That is because myostatin limits the muscle’s ability to create follistatin (FST), a protein proven to increase muscle mass and strength. [R]
Safety and Side Effects
Adverse effects are uncommon with YK 11 SARM; nonetheless, some individuals have experienced various them. Minor acne, which was more of a bother, was mentioned, as well as increased anger and some joint discomfort.
While these adverse effects are minor, they should be reported to a doctor if they continue or worsen. Some liver damage has been documented in rare cases. However, it is treatable with a liver support product.
After completing a YK 11 cycle, it is suggested that you use either tamoxifen or clomiphene for four weeks as a post-cycle therapy.
Selective androgen receptor modulators are research chemicals that may selectively bind to androgen receptors in the body. Unlike conventional anabolic compounds, which don’t spare ARs in the prostate and other sensitive body parts, SARMs are more selective in their action.
What is the half-life of YK11?
YK 11 is thought to have a potential half-life of 12-14 hours.
Does YK 11 increase muscle mass?
YK11 binds to the androgen receptor to possibly assist in suppressing myostatin synthesis in the muscle, allowing the muscle cells to produce more FST and so increase muscular development.
Why Buy YK 11 from Behemoth Labz
Behemoth Labz is the best place to buy YK 11 Myostine online.
We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee. We carry liquid YK 11.
YK 11 has demonstrated the potential ability to stimulate rapid muscle growth, revert muscle wasting, and induce fat loss in various pre-clinical studies.
However, in the absence of large-scale, randomized clinical trials, more research is needed to fully understand YK 11’s potential safety and effects.
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